(E)-N-(6-aMino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidin-5-yl)-3-(3,4-diMethoxyphenyl)acrylaMide

Base Information

Chemical Name:(E)-N-(6-aMino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidin-5-yl)-3-(3,4-diMethoxyphenyl)acrylaMide
CAS No.:187393-68-6
Molecular Formula:C₁₉H₂₄N₄O₅
Molecular Weight:388.423
Hs Code.:
Mol file:187393-68-6.mol

Synonyms:(E)-N-(6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)propenamide

Suppliers and Price of (E)-N-(6-aMino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidin-5-yl)-3-(3,4-diMethoxyphenyl)acrylaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 14 raw suppliers

Chemical Property of (E)-N-(6-aMino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidin-5-yl)-3-(3,4-diMethoxyphenyl)acrylaMide

Chemical Property:

Purity/Quality:: 99.5% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (E)-N-(6-aMino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidin-5-yl)-3-(3,4-diMethoxyphenyl)acrylaMide

There total 6 articles about (E)-N-(6-aMino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidin-5-yl)-3-(3,4-diMethoxyphenyl)acrylaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

: 52998-22-8
5,6-diamino-1,3-diethyluracil

: 39856-08-1,141236-46-6
(E)-3,4-dimethoxycinnamic chloride

: 187393-68-6
(E)-N-(6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)propenamide

Guidance literature:: With triethylamine; In dichloromethane; at 15 - 20 ℃; Temperature;

Reference yield:

: 52998-22-8
5,6-diamino-1,3-diethyluracil

: 14737-89-4
3,4-dimethoxy-trans-cinnamic acid

: 187393-68-6
(E)-N-(6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)propenamide

Guidance literature:: 3,4-dimethoxy-trans-cinnamic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; for 1.5h;

5,6-diamino-1,3-diethyluracil; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 89073-60-9
6-amino-1,3-diethyl-5-nitroso-1H,3H-pyrimidine-2,4-dione

: 187393-68-6
(E)-N-(6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)propenamide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / NH₃; sodium dithionite / H₂O / 60 °C

2: 65 percent / pyridine / CH₂Cl₂ / 16 h / 20 °C

With pyridine; sodium dithionite; ammonia; In dichloromethane; water;
DOI:10.1021/jo0358574