1,3-DIETHYL-5-NITROSO-6-AMINOURACIL

Base Information

• Chemical Name: 1,3-DIETHYL-5-NITROSO-6-AMINOURACIL
• CAS No.: 89073-60-9
• Molecular Formula: C8H12 N4 O3
• Molecular Weight: 212.208
• Hs Code.: 2933599090
• Mol file: 89073-60-9.mol

Synonyms:NSC 677517

Chemical Property of 1,3-DIETHYL-5-NITROSO-6-AMINOURACIL

Chemical Property:

• Vapor Pressure: 0.00489mmHg at 25°C
• Melting Point: 217-218°C
• Refractive Index: 1.629
• Boiling Point: 276.1ºC at 760 mmHg
• PKA: 1.14±0.70(Predicted)
• Flash Point: 120.8ºC
• PSA: 99.45000
• Density: 1.45g/cm3
• LogP: 0.61110
• Solubility.: Chloroform, DMF, DMSO,

Purity/Quality:

98%, ^*data from raw suppliers

1,3-Diethyl-5-nitroso-6-aminouracil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,3-Diethyl-5-nitroso-6-aminouracil (cas# 89073-60-9) is a compound useful in organic synthesis.

Technology Process of 1,3-DIETHYL-5-NITROSO-6-AMINOURACIL

There total 4 articles about 1,3-DIETHYL-5-NITROSO-6-AMINOURACIL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6-amino-1,3-diethyluracil (41740-15-2) → 6-amino-1,3-diethyl-5-nitroso-1H,3H-pyrimidine-2,4-dione (89073-60-9)

Guidance literature:

With sodium nitrite; In acetic acid; at 50 - 60 ℃; for 0.25h;

DOI:10.1016/j.bmcl.2013.03.070

Reference yield:

N,N'-diethylurea (623-76-7) → 6-amino-1,3-diethyl-5-nitroso-1H,3H-pyrimidine-2,4-dione (89073-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Ac₂O / 70 °C

2.1: aq. AcOH / 0.5 h / 75 °C

2.2: NaNO₂ / 1 h / 20 °C

With acetic anhydride; acetic acid;

DOI:10.1021/jm051268+

Reference yield:

N,N-diethylurea (634-95-7) → 6-amino-1,3-diethyl-5-nitroso-1H,3H-pyrimidine-2,4-dione (89073-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 2 h / 80 °C

2: sodium nitrite / acetic acid / 0.25 h / 50 - 60 °C

With sodium nitrite; In acetic acid;

DOI:10.1016/j.bmcl.2013.03.070

upstream raw materials:

6-amino-1,3-diethyluracil

N,N'-diethylurea

N,N-diethylurea

Downstream raw materials:

6-Amino-1,3-diethyl-5-[2-mercapto-5-oxo-1,5-dihydro-imidazol-(4E)-ylideneamino]-1H-pyrimidine-2,4-dione

5,6-diamino-1,3-diethyluracil

Refernces

• 1、 Meng, Zihui,Wang, Hongyi,Wang, Yiyun,Xu, Haojie,Xu, Zhibin,Xue, Min,Zheng, Zhonghui. "Separation and identification of an impurity from the istradefylline intermediate". . p. 14493 - 14499. Retrieved 2020/04/27.
• 2、 -. "Preparation method and use of istradefylline". Paragraph 0024; 0031; 0038. . Retrieved 2017/08/28.