(E)-4-((1R,2S)-2-(3,5-bis(trifluoromethyl)phenyl)cyclopropyl)but-3-en-2-one

Base Information

Chemical Name:(E)-4-((1R,2S)-2-(3,5-bis(trifluoromethyl)phenyl)cyclopropyl)but-3-en-2-one
CAS No.:1393135-63-1
Molecular Formula:C₁₅H₁₂F₆O
Molecular Weight:322.25
Hs Code.:

Synonyms:(E)-4-((1R,2S)-2-(3,5-bis(trifluoromethyl)phenyl)cyclopropyl)but-3-en-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-4-((1R,2S)-2-(3,5-bis(trifluoromethyl)phenyl)cyclopropyl)but-3-en-2-one

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Technology Process of (E)-4-((1R,2S)-2-(3,5-bis(trifluoromethyl)phenyl)cyclopropyl)but-3-en-2-one

There total 3 articles about (E)-4-((1R,2S)-2-(3,5-bis(trifluoromethyl)phenyl)cyclopropyl)but-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1379688-69-3
((1S,2S)-2-(3,5-bis(trifluoromethyl)phenyl)cyclopropyl)methanol

: 1439-36-7
1-triphenylphosphoranylidene-2-propanone

: 1393135-63-1
(E)-4-((1R,2S)-2-(3,5-bis(trifluoromethyl)phenyl)cyclopropyl)but-3-en-2-one

Guidance literature:: ((1S,2S)-2-(3,5-bis(trifluoromethyl)phenyl)cyclopropyl)methanol; With silica gel; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 3h;

1-triphenylphosphoranylidene-2-propanone; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ml3000963

Reference yield:

: 401-95-6
3,5-Bis(trifluoromethyl)benzaldehyde

: 1393135-63-1
(E)-4-((1R,2S)-2-(3,5-bis(trifluoromethyl)phenyl)cyclopropyl)but-3-en-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

1.2: 0 - 20 °C

1.3: -78 °C

2.1: diethylzinc / hexane; dichloromethane / 0.17 h / 0 °C

2.2: 0 - 20 °C

3.1: silica gel; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C

3.2: 20 °C

With diethylzinc; silica gel; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; hexane; dichloromethane; 2.1: Simmons-Smith reaction / 2.2: Simmons-Smith reaction / 3.2: Wittig reaction;
DOI:10.1021/ml3000963

Reference yield:

: 826994-13-2
(E)-3-(3,5-bis(trifluoromethyl)phenyl)prop-2-en-1-ol

: 1393135-63-1
(E)-4-((1R,2S)-2-(3,5-bis(trifluoromethyl)phenyl)cyclopropyl)but-3-en-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylzinc / hexane; dichloromethane / 0.17 h / 0 °C

1.2: 0 - 20 °C

2.1: silica gel; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C

2.2: 20 °C

With diethylzinc; silica gel; pyridinium chlorochromate; In hexane; dichloromethane; 1.1: Simmons-Smith reaction / 1.2: Simmons-Smith reaction / 2.2: Wittig reaction;
DOI:10.1021/ml3000963