826994-13-2Relevant academic research and scientific papers
Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS
Zhang, Yinan,Benmohamed, Radhia,Zhang, Wei,Kim, Jinho,Edgerly, Christina K.,Zhu, Yaoqiu,Morimoto, Richard I.,Ferrante, Robert J.,Kirsch, Donald R.,Silverman, Richard B.
supporting information; experimental part, p. 584 - 587 (2012/09/10)
Cyclohexane 1,3-diones were identified as a class of molecules exhibiting a protective effect against mutant SOD1 induced toxicity in PC-12 cells, but an optimized analogue had little or no effect on life extension in the G93A SOD1 mouse model for amyotro
Design of potent PPARα agonists
Sauerberg, Per,Mogensen, John P.,Jeppesen, Lone,Bury, Paul S.,Fleckner, Jan,Olsen, Grith S.,Jeppesen, Claus B.,Wulff, Erik M.,Pihera, Pavel,Havranek, Miroslav,Polivka, Zdenek,Pettersson, Ingrid
, p. 3198 - 3202 (2008/02/05)
Computational analysis of the ligand binding pocket of the three PPAR receptor subtypes was utilized in the design of potent PPARα agonists. Optimum PPARα potency and selectivity were obtained with substituents having van der Waals volume around 260. Compound 6 had a PPARα potency of 0.002 μM and a selectivity ratio to PPARγ and PPARδ of 410 and 2000, respectively.
