2-Bromo-4-phenylquinoline

Base Information

Chemical Name:2-Bromo-4-phenylquinoline
CAS No.:857206-12-3
Molecular Formula:C₁₅H₁₀BrN
Molecular Weight:284.155
Hs Code.:
DSSTox Substance ID:DTXSID401312727
Nikkaji Number:J2.218.618C

Synonyms:2-Bromo-4-phenylquinoline;SCHEMBL20208979;DTXSID401312727;857206-12-3

Suppliers and Price of 2-Bromo-4-phenylquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 2-Bromo-4-phenylquinoline

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:282.99966
Heavy Atom Count:17
Complexity:249

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC(=NC3=CC=CC=C32)Br

Technology Process of 2-Bromo-4-phenylquinoline

There total 3 articles about 2-Bromo-4-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 866831-73-4
2-bromo-4-iodoquinoline

: 98-80-6
phenylboronic acid

: 857206-12-3
2-bromo-4-phenylquinoline

Guidance literature:: With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; for 20h; Heating;
DOI:10.1016/j.tetlet.2005.07.137

Reference yield:

: 5855-57-2
4-phenyl-quinolin-2-ol

: 857206-12-3
2-bromo-4-phenylquinoline

Guidance literature:: With phosphorus tribromide; phosphorus(V) oxybromide;
DOI:10.1021/ja01116a013

Reference yield:

: 20151-40-0
2,4-dibromoquinoline

: 857206-12-3
2-bromo-4-phenylquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; tetrahydrofuran; hexane / 0.08 h / -78 °C

1.2: 87 percent / I₂; 4 Angstroem molecular sieves / hexane; tetrahydrofuran; diethyl ether / -78 - 20 °C

2.1: 55 percent / K₂CO₃ / Pd(PPh₃)2Cl₂ / tetrahydrofuran / 20 h / Heating

With n-butyllithium; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; diethyl ether; hexane; 2.1: Suzuki reaction;
DOI:10.1016/j.tetlet.2005.07.137