2-(Benzyloxy)-1-naphthaldehyde

Base Information

• Chemical Name: 2-(Benzyloxy)-1-naphthaldehyde
• CAS No.: 52805-48-8
• Molecular Formula: C18H14 O2
• Molecular Weight: 262.308
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID20352775
• Nikkaji Number: J2.111.512F
• Wikidata: Q27209357
• ChEMBL ID: CHEMBL1333069
• Mol file: 52805-48-8.mol

Synonyms:2-(benzyloxy)-1-naphthaldehyde;52805-48-8;2-(benzyloxy)naphthalene-1-carbaldehyde;2-phenylmethoxynaphthalene-1-carbaldehyde;2-benzyloxy-1-naphthaldehyde;MFCD00202669;2-Benzyloxy-naphthalene-1-carbaldehyde;Oprea1_219660;Oprea1_467395;MLS000692084;SCHEMBL4345200;CHEMBL1333069;DTXSID20352775;CHEBI:121112;VEMDBXGFPCYWJJ-UHFFFAOYSA-N;HMS2662N12;CCA80548;BBL023466;STK397235;AKOS000273773;SMR000333761;2-phenylmethoxy-1-naphthalenecarboxaldehyde;2-(Benzyloxy)-1-naphthaldehyde, AldrichCPR;BB 0243331;CS-0196274;FT-0680360;4H-959;E89431;EN300-6482269;AN-584/41496452;J-506233;Q27209357;Z26336486

Chemical Property of 2-(Benzyloxy)-1-naphthaldehyde

Chemical Property:

• Vapor Pressure: 2.12E-08mmHg at 25°C
• Melting Point: 121-123°C
• Boiling Point: 453.1°Cat760mmHg
• Flash Point: 210.5°C
• PSA: 26.30000
• Density: 1.192g/cm³
• LogP: 4.23130
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 262.099379685
• Heavy Atom Count: 20
• Complexity: 309

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Benzyloxy)-1-naphthaldehyde AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=C(C3=CC=CC=C3C=C2)C=O

Technology Process of 2-(Benzyloxy)-1-naphthaldehyde

There total 4 articles about 2-(Benzyloxy)-1-naphthaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzyl chloride (100-44-7) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → 2-(Benzyloxy)-1-naphthaldehyde (52805-48-8)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; for 4h; Reflux;

DOI:10.1039/c7ob00070g

Reference yield:

potassium carbonate (584-08-7) + benzyl chloride (100-44-7) → 2-(Benzyloxy)-1-naphthaldehyde (52805-48-8)

Guidance literature:

In ethanol; water;

Reference yield:

2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → 2-(Benzyloxy)-1-naphthaldehyde (52805-48-8)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

DOI:10.1016/j.ejmech.2016.07.014

upstream raw materials:

benzyl chloride

2-hydroxynaphthalene-1-carbaldehyde

potassium carbonate

Refernces

• 1、 Ye, Yan,Zhang, Bidong,Mao, Ruifeng,Zhang, Chenhua,Wang, Yulan,Xing, Jing,Liu, Yu-Chih,Luo, Xiaomin,Ding, Hong,Yang, Yaxi,Zhou, Bing,Jiang, Hualiang,Chen, Kaixian,Luo, Cheng,Zheng, Mingyue. "Discovery and optimization of selective inhibitors of protein arginine methyltransferase 5 by docking-based virtual screening". . p. 3648 - 3661. Retrieved 2017/07/11.
• 2、 Duffy,Darcy,Delorme,Dillon,Eppley,Erickson-Miller,Giampa,Hopson,Huang,Keenan,Lamb,Leong,Liu,Miller,Price,Rosen,Shah,Shaw,Smith,Stark,Tian,Tyree,Wiggall,Zhang,Luengo. "Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis". . p. 3730 - 3745. Retrieved 2007/10/03.