(2S,5S,6R,12S,13S,14R)-17-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2,6,12,14-tetramethyl-5,13-bis-triethylsilanyloxy-heptadec-7-yn-9-one

Base Information

Chemical Name:(2S,5S,6R,12S,13S,14R)-17-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2,6,12,14-tetramethyl-5,13-bis-triethylsilanyloxy-heptadec-7-yn-9-one
CAS No.:329914-21-8
Molecular Formula:C₄₆H₈₆O₅Si₃
Molecular Weight:803.442
Hs Code.:

Synonyms:(2S,5S,6R,12S,13S,14R)-17-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2,6,12,14-tetramethyl-5,13-bis-triethylsilanyloxy-heptadec-7-yn-9-one

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Chemical Property of (2S,5S,6R,12S,13S,14R)-17-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2,6,12,14-tetramethyl-5,13-bis-triethylsilanyloxy-heptadec-7-yn-9-one

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Technology Process of (2S,5S,6R,12S,13S,14R)-17-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2,6,12,14-tetramethyl-5,13-bis-triethylsilanyloxy-heptadec-7-yn-9-one

There total 3 articles about (2S,5S,6R,12S,13S,14R)-17-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2,6,12,14-tetramethyl-5,13-bis-triethylsilanyloxy-heptadec-7-yn-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: C₁₆H₃₂SiO₂SiC₆H₁₃Li

: 329914-20-7
(5R,6S,7S)-N-methyl,N-methoxy-9-benzyloxy-4,5-dimethyl-5-(triethylsilyl)oxy-2-nonanecarboxamide

: 329914-21-8
(2S,5S,6R,12S,13S,14R)-17-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2,6,12,14-tetramethyl-5,13-bis-triethylsilanyloxy-heptadec-7-yn-9-one

Guidance literature:: In tetrahydrofuran; at -78 - 0 ℃; for 1h;
DOI:10.1021/jo0056951

Reference yield:

: C₂₃H₃₇LiO₂Si

: 329914-21-8
(2S,5S,6R,12S,13S,14R)-17-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2,6,12,14-tetramethyl-5,13-bis-triethylsilanyloxy-heptadec-7-yn-9-one

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / tetrahydrofuran / 1 h / -78 - 0 °C

2: 96 percent / H₂ / Pd/CaCO₃/Pb / ethyl acetate / 22 h

3: 88 percent / tetrahydrofuran / 1 h / -78 - 0 °C

With hydrogen; Lindlar's catalyst; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo0056951

Reference yield:

: 329914-19-4
(5R,6S,7S)-N-methyl,N-methoxy-9-benzyloxy-4,5-dimethyl-5-(triethylsilyl)oxy-2-nonynecarboxamide

: 329914-21-8
(2S,5S,6R,12S,13S,14R)-17-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2,6,12,14-tetramethyl-5,13-bis-triethylsilanyloxy-heptadec-7-yn-9-one

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / H₂ / Pd/CaCO₃/Pb / ethyl acetate / 22 h

2: 88 percent / tetrahydrofuran / 1 h / -78 - 0 °C

With hydrogen; Lindlar's catalyst; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo0056951