2-(4-methoxyphenyl)-1-methyl-3,4-diphenyl-1,2-dihydroisoquinoline

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-1-methyl-3,4-diphenyl-1,2-dihydroisoquinoline
• CAS No.: 1359716-25-8
• Molecular Formula: C₂₉H₂₅NO
• Molecular Weight: 403.524
• Mol file: 1359716-25-8.mol

Synonyms:2-(4-methoxyphenyl)-1-methyl-3,4-diphenyl-1,2-dihydroisoquinoline

Chemical Property of 2-(4-methoxyphenyl)-1-methyl-3,4-diphenyl-1,2-dihydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)-1-methyl-3,4-diphenyl-1,2-dihydroisoquinoline

There total 5 articles about 2-(4-methoxyphenyl)-1-methyl-3,4-diphenyl-1,2-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(4-methoxyphenyl)-1-methyl-3,4-diphenylisoquinolin-2-ium tetrafluoroborate (1569313-83-2) → 2-(4-methoxyphenyl)-1-methyl-3,4-diphenyl-1,2-dihydroisoquinoline (1359716-25-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h; Glovebox; Inert atmosphere;

DOI:10.1002/anie.201509316

Reference yield:

N-[1-(2-iodophenyl)ethylidene]-4-methoxyaniline (1359715-98-2) + diphenyl acetylene (501-65-5) → 2-(4-methoxyphenyl)-1-methyl-3,4-diphenyl-1,2-dihydroisoquinoline (1359716-25-8) + 2-(4-methoxyphenyl)-1-methyl-3,4-diphenylisoquinolinium iodide (1359716-04-3)

Guidance literature:

With Ni(PPh₃)3Br₂; zinc; In tetrahydrofuran; acetonitrile; at 70 ℃; for 2h; Inert atmosphere;

DOI:10.1002/asia.201100834

Reference yield:

2-iodoacetophenone (2142-70-3) → 2-(4-methoxyphenyl)-1-methyl-3,4-diphenyl-1,2-dihydroisoquinoline (1359716-25-8) + 2-(4-methoxyphenyl)-1-methyl-3,4-diphenylisoquinolinium iodide (1359716-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / toluene / 10 h / Inert atmosphere; Reflux; Molecular sieve

2: Ni(PPh₃)3Br₂; zinc / tetrahydrofuran; acetonitrile / 2 h / 70 °C / Inert atmosphere

With pyridine; Ni(PPh₃)3Br₂; zinc; In tetrahydrofuran; toluene; acetonitrile;

DOI:10.1002/asia.201100834

upstream raw materials:

N-[1-(2-iodophenyl)ethylidene]-4-methoxyaniline

diphenyl acetylene

2-iodoacetophenone

4-methoxy-aniline