(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid

Base Information

Chemical Name:(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid
CAS No.:903514-45-4
Molecular Formula:C₃₈H₄₄O₅
Molecular Weight:580.764
Hs Code.:

Synonyms:(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid

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Chemical Property of (5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid

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Technology Process of (5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid

There total 9 articles about (5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 903514-44-3
(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid methyl ester

: 903514-45-4
(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid

Guidance literature:: With lithium hydroxide; In methanol; at 55 ℃; for 22h;
DOI:10.1016/j.bmcl.2006.04.059

Reference yield:

: 903514-43-2
7-(trimethylsilyl)hepta-3,6-diyn-1-ol

: 903514-45-4
(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / TBAF / tetrahydrofuran / 1 h / 0 °C

2: 45 percent / CuI; NaI; Cs₂CO₃ / dimethylformamide / 18 h / 35 °C

3: 47 percent / H₂ / P-2 Ni / ethanol / 8 h / 13 °C

4: 81 percent / DMAP; NEt₃ / CH₂Cl₂ / 15 h / 20 °C

5: 96 percent / LiOH / methanol / 22 h / 55 °C

With dmap; lithium hydroxide; copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; triethylamine; sodium iodide; P-2 Ni; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.04.059

Reference yield:

: 903514-42-1
17-hydroxy-heptadeca-5,8,11,14-tetraynoic acid methyl ester

: 903514-45-4
(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / H₂ / P-2 Ni / ethanol / 8 h / 13 °C

2: 81 percent / DMAP; NEt₃ / CH₂Cl₂ / 15 h / 20 °C

3: 96 percent / LiOH / methanol / 22 h / 55 °C

With dmap; lithium hydroxide; hydrogen; triethylamine; P-2 Ni; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.04.059