(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid methyl ester

Base Information

Chemical Name:(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid methyl ester
CAS No.:903514-44-3
Molecular Formula:C₃₉H₄₆O₅
Molecular Weight:594.791
Hs Code.:

Synonyms:(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid methyl ester

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Chemical Property of (5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid methyl ester

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Technology Process of (5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid methyl ester

There total 8 articles about (5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 903514-41-0
(5Z,8Z,11Z,14Z)-17-Hydroxy-heptadeca-5,8,11,14-tetraenoic acid methyl ester

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 903514-44-3
(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid methyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1016/j.bmcl.2006.04.059

Reference yield:

: 903514-43-2
7-(trimethylsilyl)hepta-3,6-diyn-1-ol

: 903514-44-3
(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / TBAF / tetrahydrofuran / 1 h / 0 °C

2: 45 percent / CuI; NaI; Cs₂CO₃ / dimethylformamide / 18 h / 35 °C

3: 47 percent / H₂ / P-2 Ni / ethanol / 8 h / 13 °C

4: 81 percent / DMAP; NEt₃ / CH₂Cl₂ / 15 h / 20 °C

With dmap; copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; triethylamine; sodium iodide; P-2 Ni; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.04.059

Reference yield:

: 903514-42-1
17-hydroxy-heptadeca-5,8,11,14-tetraynoic acid methyl ester

: 903514-44-3
(5Z,8Z,11Z,14Z)-17-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-heptadeca-5,8,11,14-tetraenoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / H₂ / P-2 Ni / ethanol / 8 h / 13 °C

2: 81 percent / DMAP; NEt₃ / CH₂Cl₂ / 15 h / 20 °C

With dmap; hydrogen; triethylamine; P-2 Ni; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.04.059