4-[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]-5-(methylsulfonyl)thiophene-2-carboxamidine

Base Information

Chemical Name:4-[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]-5-(methylsulfonyl)thiophene-2-carboxamidine
CAS No.:237381-54-3
Molecular Formula:C₁₅H₁₂ClN₃O₂S₃
Molecular Weight:397.93
Hs Code.:

Synonyms:4-[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]-5-(methylsulfonyl)thiophene-2-carboxamidine

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Chemical Property of 4-[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]-5-(methylsulfonyl)thiophene-2-carboxamidine

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Technology Process of 4-[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]-5-(methylsulfonyl)thiophene-2-carboxamidine

There total 3 articles about 4-[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]-5-(methylsulfonyl)thiophene-2-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 237385-10-3
methyl 4-[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]-5-(methylsulfonyl)thiophene-2-carboxylate

: 237381-54-3
4-[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]-5-(methylsulfonyl)thiophene-2-carboxamidine

Guidance literature:: With trimethylaluminum; ammonium chloride; In toluene; Heating;
DOI:10.1016/S0960-894X(01)00787-9

Reference yield:

: 237381-14-5
4-[4-(4-chlorophenyl)thiazol-2-yl]-5-methylthiothiophene-2-carboxamidine

: 237381-54-3
4-[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]-5-(methylsulfonyl)thiophene-2-carboxamidine

Guidance literature:: With m-chloroperoxybenzoic acid; acetic acid; In methanol; dichloromethane; chloroform;

Reference yield:

: 237385-94-3
methyl 4-[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxylate

: 237381-54-3
4-[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]-5-(methylsulfonyl)thiophene-2-carboxamidine

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / m-CPBA / CH₂Cl₂ / 1.5 h / 20 °C

2: 53 percent / Al(CH₃)3; NH₄Cl / toluene / Heating

With trimethylaluminum; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene;
DOI:10.1016/S0960-894X(01)00787-9