{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-morpholin-4-yl-methanone

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Chemical Name:{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-morpholin-4-yl-methanone
CAS No.:1312015-95-4
Molecular Formula:C₂₆H₃₁N₃O₄S
Molecular Weight:481.616
Hs Code.:

Synonyms:{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-morpholin-4-yl-methanone

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Chemical Property of {2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-morpholin-4-yl-methanone

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Technology Process of {2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-morpholin-4-yl-methanone

There total 15 articles about {2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-morpholin-4-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1312017-87-0
2-[2-cyclopentyl-1(R)-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-carboxylic acid

: 1312015-95-4
{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-morpholin-4-yl-methanone

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; for 14h;

Reference yield:

: 766-00-7
2-cyclopentyl-ethanol

: 1312015-95-4
{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridinium chlorochromate / dichloromethane / 3 h / 25 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

2.2: 1 h / -78 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

4.2: 1.5 h / -78 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Microwave irradiation

6.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1 h / 100 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 50 °C / 37503.8 Torr

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane; N,N-dimethyl-formamide / 14 h / 25 °C

With 4-methyl-morpholine; water; hydrogen; sodium carbonate; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate; sodium hydroxide; lithium hexamethyldisilazane; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 5623-81-4
2-cyclopentylacetaldehyde

: 1312015-95-4
{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

1.2: 1 h / -78 °C

2.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

3.2: 1.5 h / -78 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Microwave irradiation

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1 h / 100 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 50 °C / 37503.8 Torr

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane; N,N-dimethyl-formamide / 14 h / 25 °C

With 4-methyl-morpholine; water; hydrogen; sodium carbonate; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hexamethyldisilazane; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;