6-(4-Acryloylamino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]-nicotinamide

Base Information

Chemical Name:6-(4-Acryloylamino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]-nicotinamide
CAS No.:1246494-99-4
Molecular Formula:C₂₄H₃₀FN₅O₂
Molecular Weight:439.533
Hs Code.:

Synonyms:6-(4-Acryloylamino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]-nicotinamide

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Chemical Property of 6-(4-Acryloylamino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]-nicotinamide

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Technology Process of 6-(4-Acryloylamino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]-nicotinamide

There total 4 articles about 6-(4-Acryloylamino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.4%

: 1246494-87-0
6-(4-amino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide

: 814-68-6,25189-84-8
acryloyl chloride

: 1246494-99-4
6-(4-Acryloylamino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]-nicotinamide

Guidance literature:: 6-(4-amino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide; acryloyl chloride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h;

With sodium carbonate; In dichloromethane;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1246494-99-4
6-(4-Acryloylamino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: water / 120 h / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 15 h / 20 °C

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 16 h / 100 °C / Inert atmosphere; Reflux

4: dmap; triethylamine / dichloromethane / 18 h / 20 °C

With dmap; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

: 1092523-21-1
6-chloro-2-(ethylamino)pyridine-3-carboxylic acid

: 1246494-99-4
6-(4-Acryloylamino-3-fluorophenyl)-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 15 h / 20 °C

2: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 16 h / 100 °C / Inert atmosphere; Reflux

3: dmap; triethylamine / dichloromethane / 18 h / 20 °C

With dmap; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane;