(2R)-N-[1-(3-tert-butoxycarbonylaminomethylbenzyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide

Base Information

Chemical Name:(2R)-N-[1-(3-tert-butoxycarbonylaminomethylbenzyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide
CAS No.:323578-26-3
Molecular Formula:C₃₁H₄₁F₂N₃O₄
Molecular Weight:557.681
Hs Code.:

Synonyms:(2R)-N-[1-(3-tert-butoxycarbonylaminomethylbenzyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide

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Chemical Property of (2R)-N-[1-(3-tert-butoxycarbonylaminomethylbenzyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide

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Technology Process of (2R)-N-[1-(3-tert-butoxycarbonylaminomethylbenzyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide

There total 12 articles about (2R)-N-[1-(3-tert-butoxycarbonylaminomethylbenzyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: methanesulfonic acid 3-(tert-butoxycarbonylamino-methyl)-benzyl ester

: 203321-80-6
(2R)-N-(piperidin-4-yl)-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide

: 323578-26-3
(2R)-N-[1-(3-tert-butoxycarbonylaminomethylbenzyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 70 ℃; for 17h;
DOI:10.1021/jm0003135

Reference yield:

: 50541-93-0
4-amino-1-benzylpiperidine

: 323578-26-3
(2R)-N-[1-(3-tert-butoxycarbonylaminomethylbenzyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CHCl₃ / 14 h / 20 °C

2: 83 percent / H₂ / 20percent Pd(OH)2 / ethanol / 8 h / 760.05 Torr

3: 99 percent / K₂CO₃; KI / acetonitrile / 17 h / 70 °C

With hydrogen; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; potassium iodide; 20percent Pd(OH)2; In ethanol; chloroform; acetonitrile;
DOI:10.1021/jm0003135

Reference yield:

: 203321-55-5
(2R,5R)-2-(tert-butyl)-5-[(1R)-3-oxocyclopentyl]-5-phenyl-1,3-dioxolan-4-one

: 323578-26-3
(2R)-N-[1-(3-tert-butoxycarbonylaminomethylbenzyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / diethylaminosulfur trifluoride / CHCl₃ / 2.5 h / 70 °C

2: 84 percent / 4 N aq. NaOH / methanol / 15 h / 20 °C

3: 97 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CHCl₃ / 14 h / 20 °C

4: 83 percent / H₂ / 20percent Pd(OH)2 / ethanol / 8 h / 760.05 Torr

5: 99 percent / K₂CO₃; KI / acetonitrile / 17 h / 70 °C

With sodium hydroxide; diethylamino-sulfur trifluoride; hydrogen; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; potassium iodide; 20percent Pd(OH)2; In methanol; ethanol; chloroform; acetonitrile;
DOI:10.1021/jm0003135