1-(2-{2-[(1-{2-[2-(2-amino-3-methyl-pentanoylamino)-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid

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Chemical Name:1-(2-{2-[(1-{2-[2-(2-amino-3-methyl-pentanoylamino)-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid
CAS No.:260782-47-6
Molecular Formula:C₄₂H₆₅N₇O₉S
Molecular Weight:844.086
Hs Code.:

1-(2-{2-[(1-{2-[2-(2-amino-3-methyl-pentanoylamino)-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid

Synonyms:1-(2-{2-[(1-{2-[2-(2-amino-3-methyl-pentanoylamino)-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid

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Chemical Property of 1-(2-{2-[(1-{2-[2-(2-amino-3-methyl-pentanoylamino)-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid

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Technology Process of 1-(2-{2-[(1-{2-[2-(2-amino-3-methyl-pentanoylamino)-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid

There total 20 articles about 1-(2-{2-[(1-{2-[2-(2-amino-3-methyl-pentanoylamino)-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 562864-22-6
1-(2-{2-[(1-{2-[2-(2-amino-3-methyl-pentanoylamino)-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid methyl ester

: 260782-47-6
1-(2-{2-[(1-{2-[2-(2-amino-3-methyl-pentanoylamino)-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol;
DOI:10.1016/S0040-4039(99)01955-3

Reference yield:

: 260782-46-5
C₄₆H₆₈Cl₃N₇O₁₁S

: 260782-47-6
1-(2-{2-[(1-{2-[2-(2-amino-3-methyl-pentanoylamino)-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Cd/Pb; aq. NH₄OAc / tetrahydrofuran / 0.67 h / 20 °C

2: tetrabutylammonium hydroxide / tetrahydrofuran / 31.5 h / 0 °C

With Cd/Pb; ammonium acetate; tetra(n-butyl)ammonium hydroxide; In tetrahydrofuran;
DOI:10.1016/S0040-4020(03)00293-X

Reference yield:

: 562864-16-8
(S)-1-((2S,3S)-2-{(S)-2-[((S)-1-{(S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid methyl ester

: 260782-47-6
1-(2-{2-[(1-{2-[2-(2-amino-3-methyl-pentanoylamino)-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 135 mg / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt / CH₂Cl₂ / 53 h / 0 - 20 °C

2: Cd/Pb; aq. NH₄OAc / tetrahydrofuran / 0.67 h / 20 °C

3: tetrabutylammonium hydroxide / tetrahydrofuran / 31.5 h / 0 °C

With Cd/Pb; ammonium acetate; tetra(n-butyl)ammonium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(03)00293-X