N-[(1R)-2-[(3R)-3-aminopyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]-methyl}ethyl]-2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}pyridine-3-carboxamide

Base Information

Chemical Name:N-[(1R)-2-[(3R)-3-aminopyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]-methyl}ethyl]-2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}pyridine-3-carboxamide
CAS No.:1239355-17-9
Molecular Formula:C₂₇H₂₆ClF₃N₄O₄
Molecular Weight:562.976
Hs Code.:

Synonyms:N-[(1R)-2-[(3R)-3-aminopyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]-methyl}ethyl]-2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}pyridine-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1R)-2-[(3R)-3-aminopyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]-methyl}ethyl]-2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}pyridine-3-carboxamide

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[(1R)-2-[(3R)-3-aminopyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]-methyl}ethyl]-2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}pyridine-3-carboxamide

There total 1 articles about N-[(1R)-2-[(3R)-3-aminopyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]-methyl}ethyl]-2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239355-52-2
(R)-3-(benzyloxy)-2-(2-(2-chloro-4-(trifluoromethyl)phenoxy)nicotinamido)propanoic acid

: 122536-77-0,140629-77-2
3-N-tert-butoxycarbonyl-3-(R)-aminopyrrolidine

: 1239355-17-9
N-[(1R)-2-[(3R)-3-aminopyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]-methyl}ethyl]-2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}pyridine-3-carboxamide

Guidance literature:: (R)-3-(benzyloxy)-2-(2-(2-chloro-4-(trifluoromethyl)phenoxy)nicotinamido)propanoic acid; 3-N-tert-butoxycarbonyl-3-(R)-aminopyrrolidine; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 18h;

Reference yield: 23.0%

: 1239355-17-9
N-[(1R)-2-[(3R)-3-aminopyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]-methyl}ethyl]-2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}pyridine-3-carboxamide

: 100-52-7
benzaldehyde

: 1239355-19-1
2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}-N-[(1R)-2-oxo-2-{(3R)-3-[(phenylmethyl)amino]pyrrolidin-1-yl}-1-{[(phenylmethyl)oxy]methyl}ethyl]pyridine-3-carboxamide

Guidance literature:: N-[(1R)-2-[(3R)-3-aminopyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]-methyl}ethyl]-2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}pyridine-3-carboxamide; benzaldehyde; With acetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium cyanoborohydride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 18h;