4-[2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-hydroxyethyl]-3,5-dichloropyridine

Base Information

• Chemical Name: 4-[2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-hydroxyethyl]-3,5-dichloropyridine
• CAS No.: 159088-33-2
• Molecular Formula: C₁₉H₂₁Cl₂NO₃
• Molecular Weight: 382.287

Synonyms:4-[2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-hydroxyethyl]-3,5-dichloropyridine

Chemical Property of 4-[2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-hydroxyethyl]-3,5-dichloropyridine

Chemical Property:

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Technology Process of 4-[2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-hydroxyethyl]-3,5-dichloropyridine

There total 3 articles about 4-[2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-hydroxyethyl]-3,5-dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dichloro-4-picoline (100868-46-0) + ammonium chloride + 3-cyclopentyloxy-4-methoxybenzylaldehyde (67387-76-2) → 4-[2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-hydroxyethyl]-3,5-dichloropyridine (159088-33-2)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane;

Reference yield:

3,5-dichloro-4-picoline (100868-46-0) + aqueous ammonium chloride + 3-cyclopentyloxy-4-methoxybenzylaldehyde (67387-76-2) → 4-[2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-hydroxyethyl]-3,5-dichloropyridine (159088-33-2) + 2-(3,5-dichlorophenyl)-1-(4-methoxy-3-(tetrahydro-furan-3-yloxy)phenyl)ethanol + 4-methoxy-3-(tetrahydrofuran-3-yloxy)benzaldehyde (171802-82-7)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane;

Reference yield:

→ 4-[2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-hydroxyethyl]-3,5-dichloropyridine (159088-33-2)

Guidance literature:

upstream raw materials:

3,5-dichloro-4-picoline

3-cyclopentyloxy-4-methoxybenzylaldehyde

Downstream raw materials:

1-(3-cyclopentyloxy-4-methoxy-phenyl)-2-(3,5-dichloro-pyridin-4-yl)-ethanone

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