100868-46-0

Basic information

• Product Name: 3,5-Dichloro-4-Picoline
• Synonyms: 3,5-Dichloro-4-Picoline;3,5-Dichloro-4-methylpyridine;Pyridine,3,5-dichloro-4-Methyl-
• CAS NO: 100868-46-0
• Molecular Formula: C₆H₅Cl₂N
• Molecular Weight: 162.0166
• EINECS: -0
• Product Categories: pharmacetical;Pyridine
• Mol File: 100868-46-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 49 °C
• Boiling Point: 203.615 °C at 760 mmHg
• Flash Point: 95.8 °C
• Appearance: /
• Density: 1.319g/cm³
• Vapor Pressure: 0.392mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.62±0.10(Predicted)
• CAS DataBase Reference: 3,5-Dichloro-4-Picoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloro-4-Picoline(100868-46-0)
• EPA Substance Registry System: 3,5-Dichloro-4-Picoline(100868-46-0)

Safety Data

• Hazardous Substances Data: 100868-46-0(Hazardous Substances Data)

Usage

Description

3,5-Dichloro-4-Picoline, a member of the picoline family and a derivative of pyridine, is a chemical compound with the molecular formula C6H4Cl2N. It is a colorless to light yellow liquid with a strong odor, known for its role as an intermediate in the synthesis of various organic compounds, including pesticides, pharmaceuticals, dyes, and pigments. Due to its chemical properties, 3,5-Dichloro-4-Picoline is produced through chemical synthesis and is recognized for its potential toxicity, posing risks to the respiratory and central nervous systems upon ingestion or inhalation.

Uses

Used in Chemical Synthesis:
3,5-Dichloro-4-Picoline is used as an intermediate in the production of various organic compounds, including pesticides and pharmaceuticals, due to its versatile chemical properties and reactivity.
Used in Solvent Applications:
As a solvent, 3,5-Dichloro-4-Picoline is utilized in various industrial processes, providing a medium for chemical reactions and facilitating the dissolution of other substances.
Used in Dye and Pigment Manufacturing:
3,5-Dichloro-4-Picoline is employed in the manufacture of dyes and pigments, contributing to the coloration and stability of these products in different applications.
Used in Pharmaceutical Industry:
3,5-Dichloro-4-Picoline is used as a key intermediate in the synthesis of certain pharmaceuticals, playing a crucial role in the development of new drugs and medications.
Used in Pesticide Industry:
In the pesticide industry, 3,5-Dichloro-4-Picoline serves as an essential component in the formulation of various pesticides, contributing to their effectiveness in controlling pests and protecting crops.

InChI:InChI=1/C6H5Cl2N/c1-4-5(7)2-9-3-6(4)8/h2-3H,1H3

Upstream product

• 2457-47-8 3,5-dichloropyridine 
• 74-88-4 methyl iodide 
• 144-55-8 sodium hydrogencarbonate 
• 917-64-6 methyl magnesium iodide 
• 153463-65-1 3,5-dichloropyridine-4-carbonitrile 
• 108-89-4 picoline 
• 917-54-4 methyllithium 
• 38113-08-5 3,4-dihydro-2-methoxy-4-methyl-2H-pyran 

Downstream Products

• 1113061-31-6 3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide 
• 1001909-97-2 1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloro-1-pyridin-4-yl)ethanone 
• 1416002-37-3 (S)-(2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethyl)(R)-(2-(6-methoxynaphthalen-2-yl)propanoate) 
• 1416002-36-2 (R)-((R)-2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethyl) 2-(6-methoxynaphthalen-2-yl)propanoate 
• 1416002-35-1 (R,S)-(2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethyl)(R)-2-(6-methoxynaphthalen-2-yl)propanoate 
• 1415994-42-1 (1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethanol 
• 208043-54-3 [2-(3,5-Dichloro-pyridin-4-yl)-1-oxoethyl]-2,3,4-trimethoxybenzene 
• 1113061-20-3 1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloro-1-pyridin-4-yl)ethanone 
• 1160567-11-2 2-(3,5-Dichloro-pyridin-4-yl)-1-[4-methoxy-3-(4-nitro-phenoxy)-phenyl]-ethanol 
• 1001909-95-0 2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethanone 
• 1113061-23-6 (R,S)-2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethanol 
• 256442-88-3 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-phenyl-phthalazine 
• 159088-33-2 4-[2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-hydroxyethyl]-3,5-dichloropyridine 

Relevant articles and documents

A SUBSTITUTED TETRAHYDROISOQUINOLINE DERIVATIVE AS A D1 POSITIVE ALLOSTERIC MODULATOR

The present invention relates to compounds according to formula (I), which are a positive allosteric modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

Ester derivatives as phosphodiesterase inhibitors

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are new ester derivatives, methods of preparing such compounds, compositions containing them and therapeutic use thereof

Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridynyl alkylene alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.