2-nitro-5-[4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,3-triazol-4-yl)phenyl]thiophene-3-carboxamide

Base Information

Chemical Name:2-nitro-5-[4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,3-triazol-4-yl)phenyl]thiophene-3-carboxamide
CAS No.:1093878-89-7
Molecular Formula:C₁₉H₂₃N₅O₄SSi
Molecular Weight:445.574
Hs Code.:

Synonyms:2-nitro-5-[4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,3-triazol-4-yl)phenyl]thiophene-3-carboxamide

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Chemical Property of 2-nitro-5-[4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,3-triazol-4-yl)phenyl]thiophene-3-carboxamide

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Technology Process of 2-nitro-5-[4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,3-triazol-4-yl)phenyl]thiophene-3-carboxamide

There total 7 articles about 2-nitro-5-[4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,3-triazol-4-yl)phenyl]thiophene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093878-20-6
5-bromo-2-nitrothiophene-3-carboxamide

: 1093878-88-6
4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,3-triazole

: 1093878-89-7
2-nitro-5-[4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,3-triazol-4-yl)phenyl]thiophene-3-carboxamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 90 ℃; Inert atmosphere;

Reference yield:

: 766-96-1
4-bromo-1-ethynylbenzene

: 1093878-89-7
2-nitro-5-[4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,3-triazol-4-yl)phenyl]thiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylsilylazide; sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 48 h / 100 °C

2: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 85 °C / Inert atmosphere

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 90 °C / Inert atmosphere

With dmap; copper(ll) sulfate pentahydrate; trimethylsilylazide; potassium acetate; sodium carbonate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1093878-18-2
5-bromo-2-nitrothiophene-3-carbaldehyde

: 1093878-89-7
2-nitro-5-[4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,3-triazol-4-yl)phenyl]thiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 20 °C

2: toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane / carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II) / toluene / 24 h / 111 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 90 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium acetate; sodium carbonate; toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); In tetrahydrofuran; ethanol; toluene;