(S,R,E)-N-(2-Oxocyclohexyl)alanine ethyl ester p-nitrophenylhydrazone

Base Information

• Chemical Name: (S,R,E)-N-(2-Oxocyclohexyl)alanine ethyl ester p-nitrophenylhydrazone
• CAS No.: 182699-53-2
• Molecular Formula: C₁₇H₂₄N₄O₄
• Molecular Weight: 348.402
• Mol file: 182699-53-2.mol

Synonyms:(S,R,E)-N-(2-Oxocyclohexyl)alanine ethyl ester p-nitrophenylhydrazone

Chemical Property of (S,R,E)-N-(2-Oxocyclohexyl)alanine ethyl ester p-nitrophenylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,R,E)-N-(2-Oxocyclohexyl)alanine ethyl ester p-nitrophenylhydrazone

There total 1 articles about (S,R,E)-N-(2-Oxocyclohexyl)alanine ethyl ester p-nitrophenylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

(S)-alanine ethyl ester hydrochloride (1115-59-9) + (E)-1-(cyclohex-1-en-1-yl)-2-(4-nitrophenyl)diazene (25769-31-7) → (S,SR,Z)-N-(2-Oxocyclohexyl)alanine ethyl ester p-nitrophenylhydrazone + (S,S,E)-N-(2-Oxocyclohexyl)alanine ethyl ester p-nitrophenylhydrazone (182699-52-1) + (S,R,E)-N-(2-Oxocyclohexyl)alanine ethyl ester p-nitrophenylhydrazone (182699-53-2)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; for 2h; Heating;

DOI:10.1039/P19960001961

Reference yield: 60.0%

(S,R,E)-N-(2-Oxocyclohexyl)alanine ethyl ester p-nitrophenylhydrazone (182699-53-2) → (-)-(S)-N-(2-Oxocyclohexyl)alanine ethyl ester

Guidance literature:

With titanium(III) chloride; In acetone; at 25 ℃;

DOI:10.1039/P19960001961

Reference yield:

(S,R,E)-N-(2-Oxocyclohexyl)alanine ethyl ester p-nitrophenylhydrazone (182699-53-2) → (-)-(S)-N-(6-Oxocyclohex-1-enyl)alanine ethyl ester (182485-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / aq. TiCl₃ / acetone / 25 °C

2: O₂ / CHCl₃ / 2 h

With titanium(III) chloride; oxygen; In chloroform; acetone;

DOI:10.1039/P19960001961

upstream raw materials:

(S)-alanine ethyl ester hydrochloride

(E)-1-(cyclohex-1-en-1-yl)-2-(4-nitrophenyl)diazene

Downstream raw materials:

(-)-(S)-N-(6-Oxocyclohex-1-enyl)alanine ethyl ester