5R,6S-5'-benzoyl-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

Base Information

Chemical Name:5R,6S-5'-benzoyl-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine
CAS No.:1374759-49-5
Molecular Formula:C₂₄H₂₆N₂O₈S
Molecular Weight:502.545
Hs Code.:

Synonyms:5R,6S-5'-benzoyl-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

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Chemical Property of 5R,6S-5'-benzoyl-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

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Technology Process of 5R,6S-5'-benzoyl-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

There total 4 articles about 5R,6S-5'-benzoyl-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 613-90-1
benzoyl cyanide

: 1374759-44-0
5R,6S-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

: 1374759-49-5
5R,6S-5'-benzoyl-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

Guidance literature:: With triethylamine; In tetrahydrofuran; at -40 - 0 ℃; for 4h;
DOI:10.1021/ol301109z

Reference yield:

: 1374759-45-1
5R,6S-bis-TBDMS-5,6-dihydro-5-hydroxy-6-benzoylthymidine

: 1374759-49-5
5R,6S-5'-benzoyl-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

Guidance literature:: Multi-step reaction with 3 steps

1: zinc(II) chloride / diethyl ether; dichloromethane / 3 h / -80 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

3: triethylamine / tetrahydrofuran / 4 h / -40 - 0 °C

With tetrabutyl ammonium fluoride; triethylamine; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol301109z

Reference yield:

: 1374759-55-3
5R,6S-bis-TBDMS-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

: 1374759-49-5
5R,6S-5'-benzoyl-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2: triethylamine / tetrahydrofuran / 4 h / -40 - 0 °C

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran;
DOI:10.1021/ol301109z