5R,6S-bis-TBDMS-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

Base Information

Chemical Name:5R,6S-bis-TBDMS-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine
CAS No.:1374759-55-3
Molecular Formula:C₂₉H₅₀N₂O₇SSi₂
Molecular Weight:626.962
Hs Code.:

Synonyms:5R,6S-bis-TBDMS-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

Suppliers and Price of 5R,6S-bis-TBDMS-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5R,6S-bis-TBDMS-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

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Technology Process of 5R,6S-bis-TBDMS-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

There total 2 articles about 5R,6S-bis-TBDMS-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 696-63-9
4-Methoxybenzenethiol

: 1374759-45-1
5R,6S-bis-TBDMS-5,6-dihydro-5-hydroxy-6-benzoylthymidine

: 1374759-55-3
5R,6S-bis-TBDMS-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

Guidance literature:: With zinc(II) chloride; In diethyl ether; dichloromethane; at -80 ℃; for 3h;
DOI:10.1021/ol301109z

Reference yield:

: 5R,6S-bis-TBDMS-thymidine glycol

: 1374759-55-3
5R,6S-bis-TBDMS-5,6-dihydro-5-hydroxy-6-(4-methoxythiophenyl)-thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; dmap / 12 h / 0 - 25 °C

2: zinc(II) chloride / diethyl ether; dichloromethane / 3 h / -80 °C

With pyridine; dmap; zinc(II) chloride; In diethyl ether; dichloromethane;
DOI:10.1021/ol301109z