4-{2-(2,4-difluorophenoxy)-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

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Chemical Name:4-{2-(2,4-difluorophenoxy)-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one
CAS No.:1446235-19-3
Molecular Formula:C₂₂H₁₈F₂N₂O₄S
Molecular Weight:444.459
Hs Code.:

Synonyms:4-{2-(2,4-difluorophenoxy)-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

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Chemical Property of 4-{2-(2,4-difluorophenoxy)-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

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Technology Process of 4-{2-(2,4-difluorophenoxy)-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

There total 13 articles about 4-{2-(2,4-difluorophenoxy)-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1446236-29-8
4-(2-(2,4-difluorophenoxy)-5-(methylsulfonylmethyl)phenyl)-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one

: 1446235-19-3
4-{2-(2,4-difluorophenoxy)-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

Guidance literature:: 4-(2-(2,4-difluorophenoxy)-5-(methylsulfonylmethyl)phenyl)-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one; With cetyltrimethylammonim bromide; potassium hydroxide; In tetrahydrofuran; water; at 100 ℃; for 44h;

With hydrogenchloride; In tetrahydrofuran; water; pH=7;

Reference yield:

: 3-bromo-4-(2,4-difluorophenoxy)benzaldehyde

: 1446235-19-3
4-{2-(2,4-difluorophenoxy)-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol; sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C

2.1: phosphorus tribromide / dichloromethane / 3 h / 20 °C

3.1: N,N-dimethyl-formamide / 6 h / 20 °C

4.1: Oxone / methanol; water / 1 h / 20 °C

5.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / 0.25 h / Inert atmosphere

5.2: 1.25 h / 60 °C / Microwave irradiation

6.1: cetyltrimethylammonim bromide; potassium hydroxide / 1,4-dioxane; water / 44 h / 100 °C

With Oxone; sodium tetrahydroborate; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; cetyltrimethylammonim bromide; phosphorus tribromide; potassium hydroxide; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 2-bromo-4-(bromomethyl)-1-(2,4-difluorophenoxy)benzene

: 1446235-19-3
4-{2-(2,4-difluorophenoxy)-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 6 h / 20 °C

2.1: Oxone / methanol; water / 1 h / 20 °C

3.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / 0.25 h / Inert atmosphere

3.2: 1.25 h / 60 °C / Microwave irradiation

4.1: cetyltrimethylammonim bromide; potassium hydroxide / 1,4-dioxane; water / 44 h / 100 °C

With Oxone; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; cetyltrimethylammonim bromide; potassium hydroxide; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;