(R)-4-[2-(4-chlorobenzoyloxy)ethyl]cyclohexa-1,5-diene-1-carboxylic acid

Base Information

Chemical Name:(R)-4-[2-(4-chlorobenzoyloxy)ethyl]cyclohexa-1,5-diene-1-carboxylic acid
CAS No.:1616766-75-6
Molecular Formula:C₁₆H₁₅ClO₄
Molecular Weight:306.746
Hs Code.:

Synonyms:(R)-4-[2-(4-chlorobenzoyloxy)ethyl]cyclohexa-1,5-diene-1-carboxylic acid

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Chemical Property of (R)-4-[2-(4-chlorobenzoyloxy)ethyl]cyclohexa-1,5-diene-1-carboxylic acid

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Technology Process of (R)-4-[2-(4-chlorobenzoyloxy)ethyl]cyclohexa-1,5-diene-1-carboxylic acid

There total 4 articles about (R)-4-[2-(4-chlorobenzoyloxy)ethyl]cyclohexa-1,5-diene-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 201230-82-2
carbon monoxide

: 1616766-88-1
C₁₆H₁₄ClF₃O₅S

: 1616766-75-6
(R)-4-[2-(4-chlorobenzoyloxy)ethyl]cyclohexa-1,5-diene-1-carboxylic acid

Guidance literature:: carbon monoxide; C₁₆H₁₄ClF₃O₅S; With potassium acetate; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃; for 7h;

With hydrogenchloride; water; In N,N-dimethyl-formamide;
DOI:10.1039/c4cc01830c

Reference yield:

: 1616766-79-0
(R)-2-(4-oxocyclohex-2-en-1-yl)ethyl 4-chlorobenzoate

: 1616766-75-6
(R)-4-[2-(4-chlorobenzoyloxy)ethyl]cyclohexa-1,5-diene-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 3 h / -78 °C

2.1: palladium diacetate; potassium acetate; triphenylphosphine / N,N-dimethyl-formamide / 7 h / 20 °C

With potassium acetate; palladium diacetate; sodium hexamethyldisilazane; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c5ob00354g

Reference yield:

: 3-formyl-6-oxoheptyl 4-chlorobenzoate

: 1616766-75-6
(R)-4-[2-(4-chlorobenzoyloxy)ethyl]cyclohexa-1,5-diene-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: (S)-2-(pyrrolidinomethyl)pyrrolidine trifluoroacetate / hexane / 18 h / 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 3 h / -78 °C

3.1: palladium diacetate; potassium acetate; triphenylphosphine / N,N-dimethyl-formamide / 7 h / 20 °C

With (S)-2-(pyrrolidinomethyl)pyrrolidine trifluoroacetate; potassium acetate; palladium diacetate; sodium hexamethyldisilazane; triphenylphosphine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 1.1: |Aldol Condensation;
DOI:10.1039/c5ob00354g