Bis-biphenyl-4-yl-[(4R,5R)-5-(bis-biphenyl-4-yl-hydroxy-methyl)-[1,3]dioxolan-4-yl]-methanol

Base Information

• Chemical Name: Bis-biphenyl-4-yl-[(4R,5R)-5-(bis-biphenyl-4-yl-hydroxy-methyl)-[1,3]dioxolan-4-yl]-methanol
• CAS No.: 909036-71-1
• Molecular Formula: C₅₃H₄₂O₄
• Molecular Weight: 742.914
• Mol file: 909036-71-1.mol

Synonyms:Bis-biphenyl-4-yl-[(4R,5R)-5-(bis-biphenyl-4-yl-hydroxy-methyl)-[1,3]dioxolan-4-yl]-methanol

Chemical Property of Bis-biphenyl-4-yl-[(4R,5R)-5-(bis-biphenyl-4-yl-hydroxy-methyl)-[1,3]dioxolan-4-yl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bis-biphenyl-4-yl-[(4R,5R)-5-(bis-biphenyl-4-yl-hydroxy-methyl)-[1,3]dioxolan-4-yl]-methanol

There total 1 articles about Bis-biphenyl-4-yl-[(4R,5R)-5-(bis-biphenyl-4-yl-hydroxy-methyl)-[1,3]dioxolan-4-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-(4R,5R)-1,3-dioxolane-4,5-dicarboxylic acid diethyl ester (21154-13-2,60077-28-3,70561-17-0) + 4-biphenylylmagnesium bromide (3315-91-1) → Bis-biphenyl-4-yl-[(4R,5R)-5-(bis-biphenyl-4-yl-hydroxy-methyl)-[1,3]dioxolan-4-yl]-methanol (909036-71-1)

Guidance literature:

In tetrahydrofuran;

DOI:10.1002/adsc.200505167

Reference yield:

Bis-biphenyl-4-yl-[(4R,5R)-5-(bis-biphenyl-4-yl-hydroxy-methyl)-[1,3]dioxolan-4-yl]-methanol (909036-71-1) → (3aR,8aR)-4,4,8,8-Tetrakis-biphenyl-4-yl-tetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine 6-oxide

Guidance literature:

Bis-biphenyl-4-yl-[(4R,5R)-5-(bis-biphenyl-4-yl-hydroxy-methyl)-[1,3]dioxolan-4-yl]-methanol; With triethylamine; phosphorus trichloride; In tetrahydrofuran; at 0 ℃; for 1h;

With triethylamine; In tetrahydrofuran; water;

DOI:10.1002/adsc.200505167

Reference yield:

Bis-biphenyl-4-yl-[(4R,5R)-5-(bis-biphenyl-4-yl-hydroxy-methyl)-[1,3]dioxolan-4-yl]-methanol (909036-71-1) → (3aR,8aR)-4,4,8,8-Tetrakis-biphenyl-4-yl-6-oxo-tetrahydro-6λ5-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-ol

Guidance literature:

Multi-step reaction with 2 steps

1.1: PCl₃; Et₃N / tetrahydrofuran / 1 h / 0 °C

1.2: Et₃N / H₂O; tetrahydrofuran

2.1: I₂ / pyridine; H₂O / 0.33 h / 20 °C

With iodine; triethylamine; phosphorus trichloride; In tetrahydrofuran; pyridine; water;

DOI:10.1002/adsc.200505167

upstream raw materials:

trans-(4R,5R)-1,3-dioxolane-4,5-dicarboxylic acid diethyl ester

4-biphenylylmagnesium bromide