(R,R)-1,4-bis(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-amino-6-methylperhydro-1,4-diazepine

Base Information

• Chemical Name: (R,R)-1,4-bis(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-amino-6-methylperhydro-1,4-diazepine
• CAS No.: 1147862-50-7
• Molecular Formula: C₃₈H₅₅N₃O₈
• Molecular Weight: 681.87
• Mol file: 1147862-50-7.mol

Synonyms:(R,R)-1,4-bis(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-amino-6-methylperhydro-1,4-diazepine

Chemical Property of (R,R)-1,4-bis(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-amino-6-methylperhydro-1,4-diazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,R)-1,4-bis(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-amino-6-methylperhydro-1,4-diazepine

There total 1 articles about (R,R)-1,4-bis(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-amino-6-methylperhydro-1,4-diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

6-amino-6-methylperhydro-1,4-diazepine (869482-93-9) + (2S)-2-bromopentanedioic acid 1-(1,1-dimethylethyl)-5-(phenylmethyl) ester (873201-11-7) → (R,R)-1,4-bis(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-amino-6-methylperhydro-1,4-diazepine (1147862-50-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 18h;

DOI:10.1039/b818445c

Reference yield: 65.0%

bromoacetic acid tert-butyl ester (5292-43-3) + (R,R)-1,4-bis(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-amino-6-methylperhydro-1,4-diazepine (1147862-50-7) → (R,R)-1,4-bis(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-bis(tert-butoxycarbonylmethyl)amino-6-methylperhydro-1,4-diazepine (1147862-52-9)

Guidance literature:

bromoacetic acid tert-butyl ester; (R,R)-1,4-bis(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-amino-6-methylperhydro-1,4-diazepine; With potassium carbonate; In acetonitrile; at 0 - 20 ℃;

With sodium sulfate; In acetonitrile; Reflux;

DOI:10.1039/b818445c

Reference yield: 60.0%

bromoacetic acid tert-butyl ester (5292-43-3) + (R,R)-1,4-bis(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-amino-6-methylperhydro-1,4-diazepine (1147862-50-7) → (1'R,6S)-(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-4-tert-butoxycarbonylmethyl-6-bis(tert-butoxycarbonylmethyl)amino-6-methylperhydro-1,4-diazepine (1147862-51-8)

Guidance literature:

With potassium carbonate; sodium sulfate; In acetonitrile; at 0 ℃; Reflux;

DOI:10.1039/b818445c

upstream raw materials:

6-amino-6-methylperhydro-1,4-diazepine

(2S)-2-bromopentanedioic acid 1-(1,1-dimethylethyl)-5-(phenylmethyl) ester

Downstream raw materials:

(1'R,6R)-(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-amino-6-methylperhydro-1,4-diazepine

(1'R,6S)-(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-amino-6-methylperhydro-1,4-diazepine

(1'R,6S)-(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-4-tert-butoxycarbonylmethyl-6-bis(tert-butoxycarbonylmethyl)amino-6-methylperhydro-1,4-diazepine

(R,R)-1,4-bis(1'-tert-butoxycarbonyl-3'-benzyloxycarbonylpropyl)-6-bis(tert-butoxycarbonylmethyl)amino-6-methylperhydro-1,4-diazepine