Technology Process of 5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-3-pyridinesulfonamide
There total 6 articles about 5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-3-pyridinesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; sodium hydrogencarbonate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane;
at 100 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: water; sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 6 h / 100 °C
2: hydrogenchloride; water / 1,4-dioxane / 66 h / 100 °C
3: pyridine / 3 h / 20 °C
4: water; sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 18 h / 100 °C
With
pyridine; hydrogenchloride; water; sodium hydrogencarbonate;
tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: water; sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 6 h / 100 °C
2: hydrogenchloride; water / 1,4-dioxane / 66 h / 100 °C
3: pyridine / 3 h / 20 °C
4: water; sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 18 h / 100 °C
With
pyridine; hydrogenchloride; water; sodium hydrogencarbonate;
tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane;