8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yltrifluoromethanesulfonate

Base Information

• Chemical Name: 8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yltrifluoromethanesulfonate
• CAS No.: 1092565-16-6
• Molecular Formula: C₁₅H₁₀F₃N₃O₅S₂
• Molecular Weight: 433.389
• Mol file: 1092565-16-6.mol

Synonyms:8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yltrifluoromethanesulfonate

Chemical Property of 8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yltrifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yltrifluoromethanesulfonate

There total 4 articles about 8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yltrifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

trifluoromethylsulfonic anhydride (358-23-6) + 3-(6-hydroxy-1,5-naphthyridin-4-yl)benzenesulfonamide dihydrochloride → 8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yltrifluoromethanesulfonate (1092565-16-6)

Guidance literature:

With pyridine; at 20 ℃; for 3h;

Reference yield:

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide (486422-08-6) → 8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yltrifluoromethanesulfonate (1092565-16-6)

Guidance literature:

Multi-step reaction with 3 steps

1: water; sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 6 h / 100 °C

2: hydrogenchloride; water / 1,4-dioxane / 66 h / 100 °C

3: pyridine / 3 h / 20 °C

With pyridine; hydrogenchloride; water; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane;

Reference yield:

6-methoxy-1,5-naphthyridin-4-yl trifluoromethanesulfonate (394223-86-0) → 8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yltrifluoromethanesulfonate (1092565-16-6)

Guidance literature:

Multi-step reaction with 3 steps

1: water; sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 6 h / 100 °C

2: hydrogenchloride; water / 1,4-dioxane / 66 h / 100 °C

3: pyridine / 3 h / 20 °C

With pyridine; hydrogenchloride; water; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane;

upstream raw materials:

trifluoromethylsulfonic anhydride

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide

6-methoxy-1,5-naphthyridin-4-yl trifluoromethanesulfonate

3-[6-(methyloxy)-1,5-naphthyridin-4-yl]benzenesulfonamide

Downstream raw materials:

2-amino-5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-N,N-dimethyl-3-pyridinesulfonamide

5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-3-pyridinesulfonamide