Technology Process of (2S,3R)-5-Benzyloxycarbonylamino-2,3-dihydroxy-3-methyl-pentanoic acid ethyl ester
There total 6 articles about (2S,3R)-5-Benzyloxycarbonylamino-2,3-dihydroxy-3-methyl-pentanoic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanesulfonamide; AD-mix-β;
In
water; tert-butyl alcohol;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 77 percent / tetrahydrofuran / -78 °C
2.1: 85 percent / (COCl)2; DMSO / CH2Cl2 / -60 °C
3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
3.2: 78 percent / tetrahydrofuran / 20 °C
4.1: 94 percent / AD-mix-β; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C
With
oxalyl dichloride; methanesulfonamide; AD-mix-β; sodium hydride; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
2.1: Swern oxidation / 3.2: Wittig-Horner reaction / 4.1: Sharpless asymmetric dihydroxylation;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 83 percent / (COCl)2; DMSO / CH2Cl2 / -60 °C
2.1: 77 percent / tetrahydrofuran / -78 °C
3.1: 85 percent / (COCl)2; DMSO / CH2Cl2 / -60 °C
4.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
4.2: 78 percent / tetrahydrofuran / 20 °C
5.1: 94 percent / AD-mix-β; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C
With
oxalyl dichloride; methanesulfonamide; AD-mix-β; sodium hydride; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
1.1: Swern oxidation / 3.1: Swern oxidation / 4.2: Wittig-Horner reaction / 5.1: Sharpless asymmetric dihydroxylation;
