ethyl 1-(4-chlorophenyl)-3-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenylcarbamoyl)-1H-pyrazole-4-carboxylate

Base Information

Chemical Name:ethyl 1-(4-chlorophenyl)-3-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenylcarbamoyl)-1H-pyrazole-4-carboxylate
CAS No.:1224172-16-0
Molecular Formula:C₂₆H₃₂ClN₃O₆Si
Molecular Weight:546.095
Hs Code.:

Synonyms:ethyl 1-(4-chlorophenyl)-3-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenylcarbamoyl)-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 1-(4-chlorophenyl)-3-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenylcarbamoyl)-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 1-(4-chlorophenyl)-3-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenylcarbamoyl)-1H-pyrazole-4-carboxylate

There total 3 articles about ethyl 1-(4-chlorophenyl)-3-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenylcarbamoyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 755034-31-2
3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)aniline

: 1224171-94-1
1-(4-chlorophenyl)-4-(ethoxycarbonyl)-1H-pyrazole-3-carboxylic acid

: 1224172-16-0
ethyl 1-(4-chlorophenyl)-3-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenylcarbamoyl)-1H-pyrazole-4-carboxylate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: C₁₅H₁₂Cl₂N₂O₂

: 1224172-16-0
ethyl 1-(4-chlorophenyl)-3-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenylcarbamoyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / isopropyl alcohol / 2 h / 80 °C

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4.5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; isopropyl alcohol;
DOI:10.1016/j.bmcl.2015.05.008

Reference yield:

: 1224171-76-9
3-benzyl 4-ethyl 1-(4-chlorophenyl)-1H-pyrazole-3,4-dicarboxylate

: 1224172-16-0
ethyl 1-(4-chlorophenyl)-3-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenylcarbamoyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4.5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2015.05.008