4-Hydroxy-4-[(S)-((2S,6S)-3-isopropyl-6-methyl-2-oxo-2λ⁵-[1,3,2]oxazaphosphinan-2-yl)-phenyl-methyl]-cyclohexanecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-Hydroxy-4-[(S)-((2S,6S)-3-isopropyl-6-methyl-2-oxo-2λ⁵-[1,3,2]oxazaphosphinan-2-yl)-phenyl-methyl]-cyclohexanecarboxylic acid tert-butyl ester
• CAS No.: 145124-67-0
• Molecular Formula: C₂₅H₄₀NO₅P
• Molecular Weight: 465.57

Synonyms:4-Hydroxy-4-[(S)-((2S,6S)-3-isopropyl-6-methyl-2-oxo-2λ⁵-[1,3,2]oxazaphosphinan-2-yl)-phenyl-methyl]-cyclohexanecarboxylic acid tert-butyl ester

Chemical Property of 4-Hydroxy-4-[(S)-((2S,6S)-3-isopropyl-6-methyl-2-oxo-2λ⁵-[1,3,2]oxazaphosphinan-2-yl)-phenyl-methyl]-cyclohexanecarboxylic acid tert-butyl ester

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Technology Process of 4-Hydroxy-4-[(S)-((2S,6S)-3-isopropyl-6-methyl-2-oxo-2λ⁵-[1,3,2]oxazaphosphinan-2-yl)-phenyl-methyl]-cyclohexanecarboxylic acid tert-butyl ester

There total 3 articles about 4-Hydroxy-4-[(S)-((2S,6S)-3-isopropyl-6-methyl-2-oxo-2λ⁵-[1,3,2]oxazaphosphinan-2-yl)-phenyl-methyl]-cyclohexanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Ethoxy-3-isopropyl-6-methyl-[1,3,2]oxazaphosphinane → 4-Hydroxy-4-[(S)-((2S,6S)-3-isopropyl-6-methyl-2-oxo-2λ5-[1,3,2]oxazaphosphinan-2-yl)-phenyl-methyl]-cyclohexanecarboxylic acid tert-butyl ester (145124-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / acetonitrile / 80 °C

2: 1.) t-BuLi / 1.) THF, -70 deg C

With tert.-butyl lithium; In acetonitrile;

DOI:10.1021/ja00052a094

Reference yield:

(S)-N-(1-methylethyl)-4-amino-2-butanol (145124-75-0) → 4-Hydroxy-4-[(S)-((2S,6S)-3-isopropyl-6-methyl-2-oxo-2λ5-[1,3,2]oxazaphosphinan-2-yl)-phenyl-methyl]-cyclohexanecarboxylic acid tert-butyl ester (145124-67-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / CH₂Cl₂ / Heating

2: 59 percent / acetonitrile / 80 °C

3: 1.) t-BuLi / 1.) THF, -70 deg C

With tert.-butyl lithium; In dichloromethane; acetonitrile;

DOI:10.1021/ja00052a094

Reference yield:

4-oxocyclohexanecarboxylic acid tert-butyl ester (38446-95-6) + 2-Benzyl-3-isopropyl-6-methyl-[1,3,2]oxazaphosphinane 2-oxide → 4-Hydroxy-4-[(S)-((2S,6S)-3-isopropyl-6-methyl-2-oxo-2λ5-[1,3,2]oxazaphosphinan-2-yl)-phenyl-methyl]-cyclohexanecarboxylic acid tert-butyl ester (145124-67-0)

Guidance literature:

With tert.-butyl lithium; Yield given. Multistep reaction; 1.) THF, -70 deg C;

DOI:10.1021/ja00052a094

upstream raw materials:

4-oxocyclohexanecarboxylic acid tert-butyl ester

(S)-N-(1-methylethyl)-4-amino-2-butanol

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