38446-95-6

Usage

Uses

Used in Pharmaceutical Synthesis:
TERT-BUTYL 4-OXOCYCLOHEXANECARBOXYLATE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex molecular structures.
Used in Agrochemical Synthesis:
In the agrochemical industry, TERT-BUTYL 4-OXOCYCLOHEXANECARBOXYLATE is used as a precursor in the production of various agrochemicals, aiding in the development of compounds that can protect crops and enhance agricultural productivity.
Used as an Industrial Solvent:
TERT-BUTYL 4-OXOCYCLOHEXANECARBOXYLATE is utilized as a solvent in different industrial processes due to its ability to dissolve a wide range of substances, facilitating various manufacturing and processing tasks.
Safety Considerations:
It is crucial to handle TERT-BUTYL 4-OXOCYCLOHEXANECARBOXYLATE with care and adhere to proper safety protocols, as it can be harmful if ingested, inhaled, or comes into contact with the skin or eyes.

InChI:InChI=1/C11H18O3/c1-11(2,3)14-10(13)8-4-6-9(12)7-5-8/h8H,4-7H2,1-3H3

Upstream product

• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 75-65-0 tert-butyl alcohol 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 3618-04-0 4-hydroxycyclohexyl carboxylic acid ethyl ester 

Downstream Products

• 145124-67-0 4-Hydroxy-4-[(S)-((2S,6S)-3-isopropyl-6-methyl-2-oxo-2λ⁵-[1,3,2]oxazaphosphinan-2-yl)-phenyl-methyl]-cyclohexanecarboxylic acid tert-butyl ester 
• 856680-45-0 tert-butyl 4-methylidenecyclohexanecarboxylate 
• 1185732-82-4 tert-butyl 4-[[(1S,2S)-2-phenylmethoxycyclohexyl]amino]piperidine-1-carboxylate 
• 1582754-13-9 anti-tert-butyl 4-hydroxy-4-((trimethylsilyl)ethynyl)cyclohexanecarboxylate 
• 1582754-12-8 anti-tert-butyl 4-ethynyl-4-hydroxycyclohexanecarboxylate 

Relevant academic research and scientific papers

DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES

The application describes dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.

DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES

Provided herein are dihydropyrimidine derivatives which are useful in the treatment of HBV infection or HBV-induced diseases, as well as pharmaceutical or medical applications thereof.

BETUIN DERIVATIVES FOR PREVENTING OR TREATING HIV INFECTIONS

The present invention relates to compounds characterized by having a structure according to the following Formula I, or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.

COMPOUNDS WITH HIV MATURATION INHIBITORY ACTIVITY

The present invention relates to compounds characterized by having a structure according to the following Formula (I), or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.

CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

Potentiating effects of β-eudesmol-related cyclohexylidene derivatives on succinylcholine-induced neuromuscular block in isolated phrenic nerve-diaphragm muscles of normal and alloxan-diabetic mice

β-Eudesmol, a sesquiterpenoid alcohol contained in Atractylodes lancea, potentiates succinylcholine (SuCh)-induced neuromuscular blockade. The potentiating effect is greater in diabetic muscles than in normal ones. As a ligand for affinity chromatography to study the potentiating mechanism, we designed and synthesized newly β-eudesmol-related cyclohexylidene derivatives (2-(3-hydroxy-3-methylbutyl)cyclohexylidene KTE-13, 2-(3-hydroxy-3-methylbutyl)-4-cyclohexyl carboxylic acid; KTE-32 and 4-tert-butoxycarbonyl-2- (3-hydroxy-3-methylbutyl) cyclohexylidene; KTE-33). We examined the potentiating effects of those compounds in phrenic nerve-diaphragm muscle preparations of normal and alloxan-diabetic mice. KTE-33 (100 μM) potentiated more greatly SuCh-induced neuromuscular blockade in diabetic muscles than in normal ones (the potentiating ratios in normal and diabetic muscles were 6.7 and 10.6, respectively), while KTE-13 (100 μM) and -32 (200 μM) potentiated weakly. These results suggest that the ester group in KTE-33 rather than a carboxyl group in KTE-32 is important in inducing the potentiation of SuCh-induced neuromuscular blockade in diabetic state.