Technology Process of (L)-menthyl 1-carboethoxy-3-vinyl-4-piperidine acetate
There total 7 articles about (L)-menthyl 1-carboethoxy-3-vinyl-4-piperidine acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium formate; triphenylphosphine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
for 48h;
Heating;
DOI:10.1016/S0040-4020(01)86974-X
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 36 percent / K2CO3 / ethanol / 108 h / 25 °C
2: 85 percent / ammonium acetate / ethanol / 60 h / 25 °C
3: 72 percent / benzene / 24 h / Heating
4: 40 percent / dil.HCl / acetone / 18 h / 25 °C
5: 84.2 percent / tributylphosphine / tetrahydrofuran / 2 h / 25 °C
6: 80 percent / tetrabutylammonium hydrogen sulphate, sodium perborate tetrahydrate / CH2Cl2; acetic acid / 7 h / 25 °C
7: 64 percent / ammonium formate, Ph3P / Pd(PPh3)4 / tetrahydrofuran / 48 h / Heating
With
ammonium acetate; hydrogenchloride; sodium perborate; tributylphosphine; tetra(n-butyl)ammonium hydrogensulfate; ammonium formate; potassium carbonate; triphenylphosphine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; dichloromethane; acetic acid; acetone; benzene;
DOI:10.1016/S0040-4020(01)86974-X
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 57.6 percent / potassium t-butoxide / benzene; dioxane / 2.5 h / 25 °C
2: 87.3 percent / trifluoroacetic acid / CH2Cl2 / 0 °C
3: 36 percent / K2CO3 / ethanol / 108 h / 25 °C
4: 85 percent / ammonium acetate / ethanol / 60 h / 25 °C
5: 72 percent / benzene / 24 h / Heating
6: 40 percent / dil.HCl / acetone / 18 h / 25 °C
7: 84.2 percent / tributylphosphine / tetrahydrofuran / 2 h / 25 °C
8: 80 percent / tetrabutylammonium hydrogen sulphate, sodium perborate tetrahydrate / CH2Cl2; acetic acid / 7 h / 25 °C
9: 64 percent / ammonium formate, Ph3P / Pd(PPh3)4 / tetrahydrofuran / 48 h / Heating
With
ammonium acetate; hydrogenchloride; sodium perborate; tributylphosphine; potassium tert-butylate; tetra(n-butyl)ammonium hydrogensulfate; ammonium formate; potassium carbonate; triphenylphosphine; trifluoroacetic acid;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetic acid; acetone; benzene;
DOI:10.1016/S0040-4020(01)86974-X
