(L)-carbomenthyloxymethyl triphenylphosphonium bromide

Base Information

• Chemical Name: (L)-carbomenthyloxymethyl triphenylphosphonium bromide
• CAS No.: 75468-48-3
• Molecular Formula: Br*C₃₀H₃₆O₂P
• Molecular Weight: 539.492
• Mol file: 75468-48-3.mol

Synonyms:(L)-carbomenthyloxymethyl triphenylphosphonium bromide

Chemical Property of (L)-carbomenthyloxymethyl triphenylphosphonium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (L)-carbomenthyloxymethyl triphenylphosphonium bromide

There total 2 articles about (L)-carbomenthyloxymethyl triphenylphosphonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-menthol (2216-51-5) → (L)-carbomenthyloxymethyl triphenylphosphonium bromide (75468-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / 2.5 h / Inert atmosphere; Reflux

With triethylamine; In tetrahydrofuran;

DOI:10.1039/c3ob27111k

Reference yield:

(1R,2S,5R)-menthol bromoacetate (16832-20-5,32815-12-6,55284-67-8) + triphenylphosphine (603-35-0) → (L)-carbomenthyloxymethyl triphenylphosphonium bromide (75468-48-3)

Guidance literature:

In tetrahydrofuran; for 2.5h; Inert atmosphere; Reflux;

DOI:10.1039/c3ob27111k

Reference yield: 65.0%

4-bromobutyraldehyde (38694-47-2) + (L)-carbomenthyloxymethyl triphenylphosphonium bromide (75468-48-3) → 1'-(1'R,2'S,5'R)-menthyl-(E)-6-bromohex-2-enoate (162732-73-2)

Guidance literature:

With sodium hydride; In acetonitrile; for 8h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85631-3

upstream raw materials:

(-)-menthol

(1R,2S,5R)-menthol bromoacetate

triphenylphosphine

Downstream raw materials:

1'-(1'R,2'S,5'R)-menthyl-(E)-6-bromohex-2-enoate

(L)-menthyl N-benzyl-N-(t-butyloxycarbonyl)-5-amino-2E-pentenoate

(L)-menthyl N-benzyl-5-amino-2E-pentenoate

(L)-menthyl 1-carboethoxy-3-vinyl-4-piperidine acetate