di-tert-butyl 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate

Base Information

Chemical Name:di-tert-butyl 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate
CAS No.:1187668-69-4
Molecular Formula:C₂₂H₂₈N₃O₄PS
Molecular Weight:461.522
Hs Code.:

Synonyms:di-tert-butyl 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate

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Chemical Property of di-tert-butyl 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate

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Technology Process of di-tert-butyl 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate

There total 5 articles about di-tert-butyl 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 315703-02-7
3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenol

: 137348-86-8
di-tert-butyl diisopropylphosphoramide

: 1187668-69-4
di-tert-butyl 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate

Guidance literature:: 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenol; di-tert-butyl diisopropylphosphoramide; With 1H-tetrazole; In tetrahydrofuran; acetonitrile; at 20 ℃; for 16h; Inert atmosphere;

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; acetonitrile; at -40 ℃; for 0.25h; Inert atmosphere;

With water; sodium hydrogensulfite; In tetrahydrofuran; dichloromethane; acetonitrile; Inert atmosphere;

Reference yield:

: 1122-54-9
methyl (4-pyridyl) ketone

: 1187668-69-4
di-tert-butyl 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen bromide; bromine; acetic acid / 0 - 75 °C

2.1: ethanol / 3 h / Heating; Reflux

2.2: 1 h / 5 - 20 °C / pH ~ 8

3.1: 1H-tetrazole / tetrahydrofuran; acetonitrile / 16 h / 20 °C / Inert atmosphere

3.2: 0.25 h / -40 °C / Inert atmosphere

3.3: Inert atmosphere

With 1H-tetrazole; hydrogen bromide; bromine; acetic acid; In tetrahydrofuran; ethanol; acetonitrile; 2.1: Hantzsch thiazole synthesis;

Reference yield:

: 3394-05-6
N-(3-hydroxyphenyl)thiourea

: 1187668-69-4
di-tert-butyl 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 3 h / Heating; Reflux

1.2: 1 h / 5 - 20 °C / pH ~ 8

2.1: 1H-tetrazole / tetrahydrofuran; acetonitrile / 16 h / 20 °C / Inert atmosphere

2.2: 0.25 h / -40 °C / Inert atmosphere

2.3: Inert atmosphere

With 1H-tetrazole; In tetrahydrofuran; ethanol; acetonitrile; 1.1: Hantzsch thiazole synthesis;