3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate dihydrogen phosphate trifluoroacetate

Base Information

Chemical Name:3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate dihydrogen phosphate trifluoroacetate
CAS No.:1187668-70-7
Molecular Formula:C₂HF₃O₂*C₁₄H₁₂N₃O₄PS
Molecular Weight:463.331
Hs Code.:

Synonyms:3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate dihydrogen phosphate trifluoroacetate

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Chemical Property of 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate dihydrogen phosphate trifluoroacetate

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Technology Process of 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate dihydrogen phosphate trifluoroacetate

There total 5 articles about 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate dihydrogen phosphate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187668-69-4
di-tert-butyl 3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate

: 76-05-1
trifluoroacetic acid

: 1187668-70-7
3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate dihydrogen phosphate trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1122-54-9
methyl (4-pyridyl) ketone

: 1187668-70-7
3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate dihydrogen phosphate trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide; bromine; acetic acid / 0 - 75 °C

2.1: ethanol / 3 h / Heating; Reflux

2.2: 1 h / 5 - 20 °C / pH ~ 8

3.1: 1H-tetrazole / tetrahydrofuran; acetonitrile / 16 h / 20 °C / Inert atmosphere

3.2: 0.25 h / -40 °C / Inert atmosphere

3.3: Inert atmosphere

4.1: dichloromethane / 16 h / 20 °C

With 1H-tetrazole; hydrogen bromide; bromine; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; 2.1: Hantzsch thiazole synthesis;

Reference yield:

: 3394-05-6
N-(3-hydroxyphenyl)thiourea

: 1187668-70-7
3-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl-phosphate dihydrogen phosphate trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 3 h / Heating; Reflux

1.2: 1 h / 5 - 20 °C / pH ~ 8

2.1: 1H-tetrazole / tetrahydrofuran; acetonitrile / 16 h / 20 °C / Inert atmosphere

2.2: 0.25 h / -40 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: dichloromethane / 16 h / 20 °C

With 1H-tetrazole; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; 1.1: Hantzsch thiazole synthesis;