(3-formyl-8-methyl-quinolin-2-ylsulfanyl)-acetic acid methyl ester

Base Information

• Chemical Name: (3-formyl-8-methyl-quinolin-2-ylsulfanyl)-acetic acid methyl ester
• CAS No.: 885123-01-3
• Molecular Formula: C₁₄H₁₃NO₃S
• Molecular Weight: 275.328
• Mol file: 885123-01-3.mol

Synonyms:(3-formyl-8-methyl-quinolin-2-ylsulfanyl)-acetic acid methyl ester

Chemical Property of (3-formyl-8-methyl-quinolin-2-ylsulfanyl)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (3-formyl-8-methyl-quinolin-2-ylsulfanyl)-acetic acid methyl ester

There total 1 articles about (3-formyl-8-methyl-quinolin-2-ylsulfanyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-8-methyl-quinoline-3-carbaldehyde (73568-26-0) + Methyl thioglycolate (2365-48-2) → (3-formyl-8-methyl-quinolin-2-ylsulfanyl)-acetic acid methyl ester (885123-01-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 35 ℃; for 3h;

DOI:10.1021/jo052640w

Reference yield:

(3-formyl-8-methyl-quinolin-2-ylsulfanyl)-acetic acid methyl ester (885123-01-3) → ethyl N-{[4-(4-methoxybenzyl)-10-methyl-3-oxo-2,3,4,5-tetrahydro[1,4]thiazepino[7,6-b]quinolin-5-yl]carbonyl}glycinate

Guidance literature:

Multi-step reaction with 2 steps

1.1: KOH / ethanol / 1.5 h / 30 °C

2.1: methanol; dimethylsulfoxide; tetrahydrofuran / 1 h / 20 °C

2.2: 68 percent / methanol; dimethylsulfoxide; tetrahydrofuran / 24 h / 60 °C

With potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; 2.2: Ugi condensation;

DOI:10.1021/jo052640w

upstream raw materials:

2-chloro-8-methyl-quinoline-3-carbaldehyde

Methyl thioglycolate