Technology Process of (+/-)-7-benzyloxy-3-(1,4-dioxaspiro[4.5]decan-8-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol
There total 9 articles about (+/-)-7-benzyloxy-3-(1,4-dioxaspiro[4.5]decan-8-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tris(acetoxy)borohydride;
In
dichloromethane;
at 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1016/j.bmc.2010.09.026
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere
2.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux
2.2: 1 h / Cooling with ice
3.1: potassium carbonate / acetone / 4 h / Reflux
4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C
5.1: methanol; magnesium / 5 h / Reflux
6.1: sodium tris(acetoxy)borohydride / dichloromethane / 16 h
With
methanol; aluminum (III) chloride; sodium tetrahydroborate; phosphorus pentoxide; sodium tris(acetoxy)borohydride; potassium carbonate; magnesium;
In
dichloromethane; 1,2-dichloro-ethane; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux
1.2: 1 h / Cooling with ice
2.1: potassium carbonate / acetone / 4 h / Reflux
3.1: sodium tetrahydroborate; methanol / 1 h / 20 °C
4.1: methanol; magnesium / 5 h / Reflux
5.1: sodium tris(acetoxy)borohydride / dichloromethane / 16 h
With
methanol; aluminum (III) chloride; sodium tetrahydroborate; sodium tris(acetoxy)borohydride; potassium carbonate; magnesium;
In
dichloromethane; acetone;
