(+/-)-7-benzyloxy-3-(1,4-dioxaspiro[4.5]decan-8-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Base Information

Chemical Name:(+/-)-7-benzyloxy-3-(1,4-dioxaspiro[4.5]decan-8-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol
CAS No.:1253197-37-3
Molecular Formula:C₂₅H₃₁NO₄
Molecular Weight:409.525
Hs Code.:

Synonyms:(+/-)-7-benzyloxy-3-(1,4-dioxaspiro[4.5]decan-8-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

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Chemical Property of (+/-)-7-benzyloxy-3-(1,4-dioxaspiro[4.5]decan-8-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

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Technology Process of (+/-)-7-benzyloxy-3-(1,4-dioxaspiro[4.5]decan-8-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

There total 9 articles about (+/-)-7-benzyloxy-3-(1,4-dioxaspiro[4.5]decan-8-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1253197-26-0
(+/-)-7-benzyloxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 1253197-37-3
(+/-)-7-benzyloxy-3-(1,4-dioxaspiro[4.5]decan-8-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.09.026

Reference yield:

: 81593-56-8
[[2-(3-Methoxy-phenyl)-ethyl]-(toluene-4-sulfonyl)-amino]-acetic acid

: 1253197-37-3
(+/-)-7-benzyloxy-3-(1,4-dioxaspiro[4.5]decan-8-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux

2.2: 1 h / Cooling with ice

3.1: potassium carbonate / acetone / 4 h / Reflux

4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

5.1: methanol; magnesium / 5 h / Reflux

6.1: sodium tris(acetoxy)borohydride / dichloromethane / 16 h

With methanol; aluminum (III) chloride; sodium tetrahydroborate; phosphorus pentoxide; sodium tris(acetoxy)borohydride; potassium carbonate; magnesium; In dichloromethane; 1,2-dichloro-ethane; acetone;

Reference yield:

: 81593-57-9
7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one

: 1253197-37-3
(+/-)-7-benzyloxy-3-(1,4-dioxaspiro[4.5]decan-8-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux

1.2: 1 h / Cooling with ice

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

4.1: methanol; magnesium / 5 h / Reflux

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 16 h

With methanol; aluminum (III) chloride; sodium tetrahydroborate; sodium tris(acetoxy)borohydride; potassium carbonate; magnesium; In dichloromethane; acetone;