3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride

Base Information

Chemical Name:3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride
CAS No.:1308690-57-4
Molecular Formula:C₂₅H₂₈N₈OS*ClH
Molecular Weight:525.077
Hs Code.:

Synonyms:3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride

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Chemical Property of 3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride

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Technology Process of 3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride

There total 10 articles about 3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1308689-70-4
3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide

: 1308690-57-4
3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 5h;

Reference yield:

: 295349-70-1
1-ethyl-4-(5-nitropyridin-2-yl)piperazine

: 1308690-57-4
3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C

2: sodium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 120 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 5 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 5308-25-8
4-ethylpiperazine

: 1308690-57-4
3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 24 h / 70 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C

3: sodium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 120 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 5 h / 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water;