(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2S)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

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Chemical Name:(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2S)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate
CAS No.:1410809-87-8
Molecular Formula:C₂₆H₃₂N₂O₆
Molecular Weight:468.55
Hs Code.:

Synonyms:(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2S)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

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Chemical Property of (S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2S)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

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Technology Process of (S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2S)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

There total 5 articles about (S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2S)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093192-07-4
(S)-2-amino-3-(tert-butoxycarbonylamino)-3-methylbutanoic acid methyl ester

: 1410809-86-7
4-(((1S,2S)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzoic acid

: 1410809-87-8
(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2S)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

: 1411940-90-3
(4S,5S)-diisopropyl-2-((1S,2S)-2-(acetoxymethyl)cyclopropyl)-1,3-dioxoline-4,5-dicarboxylate

: 1410809-87-8
(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2S)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 2 h / 80 °C

2.1: triphenylphosphine / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere

3.1: triethylamine / Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

4.2: pH 4

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5 h / 20 °C

With water; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1410809-84-5
((1S*,2S*)-2-(2,2-dibromovinyl)cyclopropyl)methyl acetate

: 1410809-87-8
(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2S)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

2.2: pH 4

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5 h / 20 °C

With water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;