Dimethyl 1-(p-bromophenyl)-1-hydroxy-4-methyl-1H-pyrrolo<2,1-c>-1,4-thiazine-7,8-dicarboxylate

Base Information

• Chemical Name: Dimethyl 1-(p-bromophenyl)-1-hydroxy-4-methyl-1H-pyrrolo<2,1-c>-1,4-thiazine-7,8-dicarboxylate
• CAS No.: 57132-31-7
• Molecular Formula: C₁₈H₁₆BrNO₅S
• Molecular Weight: 438.299

Synonyms:Dimethyl 1-(p-bromophenyl)-1-hydroxy-4-methyl-1H-pyrrolo<2,1-c>-1,4-thiazine-7,8-dicarboxylate

Chemical Property of Dimethyl 1-(p-bromophenyl)-1-hydroxy-4-methyl-1H-pyrrolo<2,1-c>-1,4-thiazine-7,8-dicarboxylate

Chemical Property:

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Technology Process of Dimethyl 1-(p-bromophenyl)-1-hydroxy-4-methyl-1H-pyrrolo<2,1-c>-1,4-thiazine-7,8-dicarboxylate

There total 3 articles about Dimethyl 1-(p-bromophenyl)-1-hydroxy-4-methyl-1H-pyrrolo<2,1-c>-1,4-thiazine-7,8-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-[2-(4'-bromophenyl)-2-oxoethyl]-4-methylthiazolium bromide (57132-40-8) + dimethyl acetylenedicarboxylate (762-42-5) → Dimethyl 1-(p-bromophenyl)-1-hydroxy-4-methyl-1H-pyrrolo<2,1-c>-1,4-thiazine-7,8-dicarboxylate (57132-31-7)

Guidance literature:

With triethylamine; In water; N,N-dimethyl-formamide; for 2h; Ambient temperature;

DOI:10.1039/p19960000629

Reference yield:

para-bromophenacyl bromide (99-73-0,132309-76-3) → Dimethyl 1-(p-bromophenyl)-1-hydroxy-4-methyl-1H-pyrrolo<2,1-c>-1,4-thiazine-7,8-dicarboxylate (57132-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / acetone / 48 h / Heating

2: 87 percent / Et₃N / dimethylformamide; H₂O / 2 h / Ambient temperature

With triethylamine; In water; N,N-dimethyl-formamide; acetone;

DOI:10.1039/p19960000629

Reference yield:

→ Dimethyl 1-(p-bromophenyl)-1-hydroxy-4-methyl-1H-pyrrolo<2,1-c>-1,4-thiazine-7,8-dicarboxylate (57132-31-7)

Guidance literature:

Ylid (6, R=p-Br-C6H4-), Acetylendicarbonsaeuredimethylester;

DOI:10.1021/jo00864a002

upstream raw materials:

3-[2-(4'-bromophenyl)-2-oxoethyl]-4-methylthiazolium bromide

dimethyl acetylenedicarboxylate

para-bromophenacyl bromide

Downstream raw materials:

1-(4-bromo-phenyl)-1-(cis-2-ethoxycarbonyl-vinyloxy)-4-methyl-1H-pyrrolo[2,1-c][1,4]thiazine-7,8-dicarboxylic acid dimethyl ester

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