dimethyl [(7Z)-5,7-dihydro-4-diethylamino-7-(4-ethylphenylmethylene)-2-methylthiofuro[3,4-d]pyrimidin-5-yl]phosphate

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Chemical Name:dimethyl [(7Z)-5,7-dihydro-4-diethylamino-7-(4-ethylphenylmethylene)-2-methylthiofuro[3,4-d]pyrimidin-5-yl]phosphate
CAS No.:1416952-45-8
Molecular Formula:C₂₂H₃₀N₃O₄PS
Molecular Weight:463.538
Hs Code.:

Synonyms:dimethyl [(7Z)-5,7-dihydro-4-diethylamino-7-(4-ethylphenylmethylene)-2-methylthiofuro[3,4-d]pyrimidin-5-yl]phosphate

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Chemical Property of dimethyl [(7Z)-5,7-dihydro-4-diethylamino-7-(4-ethylphenylmethylene)-2-methylthiofuro[3,4-d]pyrimidin-5-yl]phosphate

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Technology Process of dimethyl [(7Z)-5,7-dihydro-4-diethylamino-7-(4-ethylphenylmethylene)-2-methylthiofuro[3,4-d]pyrimidin-5-yl]phosphate

There total 2 articles about dimethyl [(7Z)-5,7-dihydro-4-diethylamino-7-(4-ethylphenylmethylene)-2-methylthiofuro[3,4-d]pyrimidin-5-yl]phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1416952-35-6
C₂₀H₂₃N₃OS

: 868-85-9
Dimethyl phosphite

: 1416952-45-8
dimethyl [(7Z)-5,7-dihydro-4-diethylamino-7-(4-ethylphenylmethylene)-2-methylthiofuro[3,4-d]pyrimidin-5-yl]phosphate

Guidance literature:: With potassium tert-butylate; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h; regioselective reaction;
DOI:10.1002/adsc.201200276

Reference yield:

: 40307-11-7
1-ethyl-4-ethynylbenzene

: 587878-86-2
4-chloro-6-diethylamino-2-methylsulfanyl-pyrimidine-5-carbaldehyde

: 1416952-45-8
dimethyl [(7Z)-5,7-dihydro-4-diethylamino-7-(4-ethylphenylmethylene)-2-methylthiofuro[3,4-d]pyrimidin-5-yl]phosphate

Guidance literature:: Multi-step reaction with 2 steps

2: potassium tert-butylate / 1,2-dichloro-ethane / 0.5 h / 20 °C

With potassium tert-butylate; In 1,2-dichloro-ethane; 1: |Sonogashira Cross-Coupling;
DOI:10.1002/adsc.201200276