(S)-2-Acetylamino-3-[3-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid benzyl ester

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Chemical Name:(S)-2-Acetylamino-3-[3-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid benzyl ester
CAS No.:218927-28-7
Molecular Formula:C₂₇H₃₄N₂O₇
Molecular Weight:498.576
Hs Code.:

Synonyms:(S)-2-Acetylamino-3-[3-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid benzyl ester

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Chemical Property of (S)-2-Acetylamino-3-[3-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid benzyl ester

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Technology Process of (S)-2-Acetylamino-3-[3-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid benzyl ester

There total 4 articles about (S)-2-Acetylamino-3-[3-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 218927-25-4
(Z)-2-Acetylamino-3-[3-((Z)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid benzyl ester

: 218927-28-7
(S)-2-Acetylamino-3-[3-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid benzyl ester

Guidance literature:: With hydrogen; benzene; In methanol; for 6h; under 2068.6 Torr; Ambient temperature;
DOI:10.1039/a805350b

Reference yield:

: 591-18-4
1-Bromo-3-iodobenzene

: 218927-28-7
(S)-2-Acetylamino-3-[3-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / NaHCO₃, Bu₄NCl, hydroquinone / Pd(OAc)2 / dimethylformamide / 18 h / 60 °C

2: 57 percent / NaHCO₃, Bu₄NCl, hydroquinone / Pd(OAc)2 / dimethylformamide / 85 °C

3: 98 percent / H₂ / >⁽¹⁺⁾*OTf^(1-) / methanol / 6 h / 2068.6 Torr / Ambient temperature

With tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; hydroquinone; palladium diacetate; benzene; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/a805350b

Reference yield:

: 55477-80-0
methyl 2-[(tert-butoxycarbonyl)amino]acrylate

: 218927-28-7
(S)-2-Acetylamino-3-[3-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / NaHCO₃, Bu₄NCl, hydroquinone / Pd(OAc)2 / dimethylformamide / 18 h / 60 °C

2: 57 percent / NaHCO₃, Bu₄NCl, hydroquinone / Pd(OAc)2 / dimethylformamide / 85 °C

3: 98 percent / H₂ / >⁽¹⁺⁾*OTf^(1-) / methanol / 6 h / 2068.6 Torr / Ambient temperature

With tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; hydroquinone; palladium diacetate; benzene; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/a805350b