55477-80-0Relevant articles and documents
Synthesis of β-substituted alanines via Michael addition of nucleophiles to dehydroalanine derivatives
Ferreira,Maia,Monteiro,Sacramento,Sebastiao
, p. 3317 - 3324 (2000)
The synthesis of β-substituted alanines was carried out. It was done through Michael addition of nucleophiles to dehydroalanine derivatives. The same method could be applied to dipeptides containing dehydroalanine. Improved results were obtained when the
Synthesis of a Novel Rhizobitoxine-Like Triazole-Containing Amino Acid
Boibessot, Thibaut,Bénimèlis, David,Jean, Marion,Benfodda, Zohra,Meffre, Patrick
, p. 2685 - 2688 (2016/11/30)
The synthesis of the four stereoisomers of a new 1,2,3-triazole analogue of rhizobitoxine from serine is described. The key step is a Huisgen 1,3-dipolar cycloaddition on an ethynylglycine synthon.
A simple approach for the synthesis of new pyrimidinyl α-amino acids
Elmarrouni, Abdelatif,Güell, Mireia,Collell, Cristina,Heras, Montserrat
experimental part, p. 612 - 623 (2010/09/14)
A simple synthetic method for the preparation of optically active pyrimidinyl α-amino acids is presented. A nucleophilic ipso-substitution reaction between 2-(benzylsulfonyl)-4-isopropoxypyrimidines and a nucleophilic side chain of several protected natural α-amino acids is investigated to obtain new pyrimidin-2-yl α-amino acids. A detailed optimisation study of this reaction is discussed. Moreover, the selective O-alkylation of 2-(benzylsulfanyl)-4(3H)pyrimidinones with a hydroxylic side chain of some natural α-amino acids under Mitsunobu conditions is studied as a method to prepare new pyrimidin-4-yl α-aminoesters.
