(2S,4R)-1-(2-cyanoethyl)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2S,4R)-1-(2-cyanoethyl)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester
CAS No.:933469-68-2
Molecular Formula:C₉H₁₄N₂O₃
Molecular Weight:198.222
Hs Code.:

Synonyms:(2S,4R)-1-(2-cyanoethyl)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester

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Chemical Property of (2S,4R)-1-(2-cyanoethyl)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester

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Technology Process of (2S,4R)-1-(2-cyanoethyl)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester

There total 1 articles about (2S,4R)-1-(2-cyanoethyl)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 107-13-1,25014-41-9
acrylonitrile

: 933469-68-2
(2S,4R)-1-(2-cyanoethyl)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 12h; Heating;
DOI:10.1016/j.tetlet.2007.01.046

Reference yield:

: 933469-68-2
(2S,4R)-1-(2-cyanoethyl)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester

: C₁₆H₁₉F₃N₂O₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / methanol / 6 h / 80 °C / 3102.97 Torr

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C

4.1: acetic acid / water / 36 h / 20 °C

With 1H-imidazole; hydrogen; sodium hydride; acetic acid; In methanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 933469-68-2
(2S,4R)-1-(2-cyanoethyl)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester

: 1613630-08-2
(8R,9aS)-8-[(triethylsilyl)oxy]-2-[3-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / methanol / 6 h / 80 °C / 3102.97 Torr

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C

With 1H-imidazole; hydrogen; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;