4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine

Base Information

• Chemical Name: 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine
• CAS No.: 101411-57-8
• Molecular Formula: C₂₁H₂₃Cl₂NO₆
• Molecular Weight: 456.323

Synonyms:4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine

Chemical Property of 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine

Chemical Property:

Purity/Quality:

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Technology Process of 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine

There total 4 articles about 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-propyne (101411-65-8) → 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine (101411-57-8)

Guidance literature:

With sulfuric acid; mercury(II) sulfate; In 1,4-dioxane; water; at 60 ℃; for 2h;

DOI:10.1021/jm00105a004

Reference yield:

sulfuric acid (7664-93-9) + 1-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-propyne (101411-65-8) + mercury(II) sulfate → 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine (101411-57-8)

Guidance literature:

In 1,4-dioxane; water;

Reference yield:

cycl-isopropylidene malonate (2033-24-1) + 2-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxy}acetic acid (90445-15-1) → 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine (101411-57-8)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jm00105a004

upstream raw materials:

cycl-isopropylidene malonate

2-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxy}acetic acid

1-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-propyne

sulfuric acid

Downstream raw materials:

2-<<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyrid-2-yl>methoxy>methyl>-2-methyloxirane

1-amino-3-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-hydroxy-2-methylpropane

4-(2,3-Dichloro-phenyl)-2-[2-hydroxy-2-methyl-3-(pyrimidin-2-ylsulfanyl)-propoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

4-(2,3-Dichloro-phenyl)-2-[2-hydroxy-2-methyl-3-(pyrimidin-2-ylamino)-propoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

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