1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}propan-2-ol

Base Information

• Chemical Name: 1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}propan-2-ol
• CAS No.: 101411-58-9
• Molecular Formula: C₂₁H₂₅Cl₂NO₆
• Molecular Weight: 458.339

Synonyms:1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}propan-2-ol

Chemical Property of 1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}propan-2-ol

Chemical Property:

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Technology Process of 1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}propan-2-ol

There total 2 articles about 1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine (101411-57-8) → 1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}propan-2-ol (101411-58-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 5h; Ambient temperature;

DOI:10.1021/jm00105a004

Reference yield:

2-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxy}acetic acid (90445-15-1) → 1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}propan-2-ol (101411-58-9)

Guidance literature:

Multi-step reaction with 2 steps

2: 41 percent / NaBH₄ / ethanol / 5 h / Ambient temperature

With sodium tetrahydroborate; In ethanol;

DOI:10.1021/jm00105a004

Reference yield: 30.0%

methyllithium (917-54-4) + 1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}propan-2-ol (101411-58-9) → 4-(2,3-Dichloro-phenyl)-2-(2-hydroxy-2-methyl-propoxymethyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester (101411-61-4)

Guidance literature:

In tetrahydrofuran; for 16h; Ambient temperature;

DOI:10.1021/jm00105a004

upstream raw materials:

4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine

2-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxy}acetic acid

Downstream raw materials:

1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-(2-furyl)-2-hydroxypropane

1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxy-carbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-hydroxy-2-(2-pyridylmethyl)propane

4-(2,3-Dichloro-phenyl)-2-(2-hydroxy-2-methyl-propoxymethyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

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