(3R)-8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Base Information

Chemical Name:(3R)-8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide
CAS No.:960003-32-1
Molecular Formula:C₂₂H₂₇N₃O₃
Molecular Weight:381.475
Hs Code.:

Synonyms:(3R)-8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

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Chemical Property of (3R)-8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

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Technology Process of (3R)-8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

There total 2 articles about (3R)-8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 856698-45-8
8-hydroxy-2,3-dimethyl-7-[3-(2-methylphenyl)-3-oxopropyl]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

: 960003-32-1
(3R)-8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Guidance literature:: With potassium tert-butylate; hydrogen; RuCl₂[(S)-Xyl-P-Phos][(S)-DAIPEN]; In isopropyl alcohol; tert-butyl alcohol; at 70 ℃; for 96h; under 60006 Torr;
DOI:10.1016/j.tetasy.2008.05.013

Reference yield:

: 856698-45-8
8-hydroxy-2,3-dimethyl-7-[3-(2-methylphenyl)-3-oxopropyl]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

: (3S)-8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)-propyl]-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

: 960003-32-1
(3R)-8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Guidance literature:: 8-hydroxy-2,3-dimethyl-7-[3-(2-methylphenyl)-3-oxopropyl]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide; With potassium tert-butylate; hydrogen; trans-RuCl₂((S)-2,2'-bis(di-3,5-xylylphosphino)-1,1'-binaphthyl)((S)-1,1-di(4-anisyl)-2-isopropyl-1,2-ethylenediamine); In isopropyl alcohol; tert-butyl alcohol; at 70 ℃; for 20h; under 18751.9 Torr;

With ammonium chloride; In dichloromethane; water; Product distribution / selectivity;

Reference yield: 54.0%

: 960003-32-1
(3R)-8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: (9S)-2,3-dimethyl-9-(2-methylphenyl)-7H-8,9-dihydro-pyrano[2,3-c]-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide fumaric acid salt

Guidance literature:: (3R)-8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide; With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.25h;

(2E)-but-2-enedioic acid; In acetone; at 0 - 50 ℃; for 18h;