8-hydroxy-2,3-dimethyl-7-[3-(2-methylphenyl)-3-oxopropyl]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Base Information

• Chemical Name: 8-hydroxy-2,3-dimethyl-7-[3-(2-methylphenyl)-3-oxopropyl]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide
• CAS No.: 856698-45-8
• Molecular Formula: C₂₂H₂₅N₃O₃
• Molecular Weight: 379.459

Synonyms:8-hydroxy-2,3-dimethyl-7-[3-(2-methylphenyl)-3-oxopropyl]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Chemical Property of 8-hydroxy-2,3-dimethyl-7-[3-(2-methylphenyl)-3-oxopropyl]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 8-hydroxy-2,3-dimethyl-7-[3-(2-methylphenyl)-3-oxopropyl]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

There total 3 articles about 8-hydroxy-2,3-dimethyl-7-[3-(2-methylphenyl)-3-oxopropyl]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

8-hydroxy-2,3-dimethyl-7-[3-oxo-3-(2-methylphenyl)-propyl]-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide fumaric acid salt → 8-hydroxy-2,3-dimethyl-7-[3-(2-methylphenyl)-3-oxopropyl]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (856698-45-8)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 54.0%

7-dimethylaminomethyl-8-hydroxy-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (498529-52-5) + 1-[1-(2-methylphenyl)vinyl]pyrrolidine (156004-72-7) → 8-hydroxy-2,3-dimethyl-7-[3-(2-methylphenyl)-3-oxopropyl]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (856698-45-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1016/j.tetasy.2008.05.013

Reference yield:

7-dimethylaminomethyl-8-hydroxy-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide iodide salt + 1-[1-(2-methylphenyl)vinyl]pyrrolidine (156004-72-7) → 8-hydroxy-2,3-dimethyl-7-[3-(2-methylphenyl)-3-oxopropyl]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (856698-45-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 4h;

DOI:10.1021/jm7010063

upstream raw materials:

1-[1-(2-methylphenyl)vinyl]pyrrolidine

7-dimethylaminomethyl-8-hydroxy-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Downstream raw materials:

(3R)-8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

8-hydroxy-7-[3-hydroxy-3-(2-methylphenyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

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