N-(3,3-dimethylpiperidin-4-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetamide

Base Information

Chemical Name:N-(3,3-dimethylpiperidin-4-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetamide
CAS No.:1242847-45-5
Molecular Formula:C₂₅H₃₆N₄O₄S
Molecular Weight:488.651
Hs Code.:

Synonyms:N-(3,3-dimethylpiperidin-4-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3,3-dimethylpiperidin-4-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(3,3-dimethylpiperidin-4-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetamide

There total 11 articles about N-(3,3-dimethylpiperidin-4-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1306755-16-7
C₃₂H₄₂N₄O₄S

: 1242847-45-5
N-(3,3-dimethylpiperidin-4-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; under 6750.68 Torr;

Reference yield:

: 29709-35-1
1-(2-aminoethyl)pyrrole

: 1242847-45-5
N-(3,3-dimethylpiperidin-4-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2.1: polyphosphoric acid / 5 h / 90 °C

3.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / 1500.15 Torr

4.1: triethylamine / dichloromethane / 20 °C

5.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

5.2: 0 °C

6.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

7.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 20 °C / 6750.68 Torr

With 1-hydroxy-7-aza-benzotriazole; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 1242850-13-0
C₁₁H₁₄N₂O₂

: 1242847-45-5
N-(3,3-dimethylpiperidin-4-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / 1500.15 Torr

2.1: triethylamine / dichloromethane / 20 °C

3.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

3.2: 0 °C

4.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

5.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 20 °C / 6750.68 Torr

With 1-hydroxy-7-aza-benzotriazole; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;